WormBase Tree Display for Gene: WBGene00005021
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| WBGene00005021 | SMap | S_parent | Sequence | R10E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sqv-3 | Person_evidence | WBPerson268 | |||||
| WBPerson1983 | |||||||||
| Sequence_name | R10E11.4 | ||||||||
| Molecular_name | R10E11.4 | ||||||||
| R10E11.4.1 | |||||||||
| CE00306 | |||||||||
| Other_name | svh-10 | ||||||||
| CELE_R10E11.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | sqv-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 11 Sep 2019 12:48:59 | WBPerson1983 | Name_change | CGC_name | sqv-3 | ||||
| Other_name | svh-10 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sqv | ||||||||
| Allele (23) | |||||||||
| Legacy_information | [Herman T] sqv for squashed vulva. morphology of L4 vulva abnormal (invagination considerably reduced). hermaphrodites self-sterile. | ||||||||
| [C.elegansII] n2823 : morphology of L4 vulva abnormal(invagination considerablyreduced); hermaphrodites self-sterile. OA2: n2841, n2842. Cloned: encodes predicted protein with similarity to beta 1,4 galactosyltransferase. [MT] | |||||||||
| Strain | WBStrain00027291 | ||||||||
| WBStrain00027295 | |||||||||
| WBStrain00027296 | |||||||||
| WBStrain00027297 | |||||||||
| WBStrain00035631 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00000269 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00012206 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sqv-3 encodes a beta(1,4)-galactosyltransferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos, vulval morphogenesis, and chondroitin synthesis; SQV-3 is orthologous to human human galactosyltransferase I (B4GALT7; OMIM:604327, mutated in the progeroid form of Ehlers-Danlos syndrome); sqv-3 transgenically rescues hamster cells lacking galactosyl transferase I; the common requirement for SQV-3 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. | Paper_evidence | WBPaper00003405 | |||||
| WBPaper00003406 | |||||||||
| WBPaper00003906 | |||||||||
| WBPaper00004348 | |||||||||
| WBPaper00012779 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables galactosyltransferase activity. Involved in several processes, including egg-laying behavior; positive regulation of axon regeneration; and proteoglycan biosynthetic process. Located in membrane. Used to study Ehlers-Danlos syndrome. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 1. Is an ortholog of human B4GALT7 (beta-1,4-galactosyltransferase 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:13359 | Homo sapiens | Paper_evidence | WBPaper00013167 | ||||
| Accession_evidence | OMIM | 130070 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Sep 2021 00:00:00 | ||||||||
| Potential_model | DOID:0080738 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:930) | |||||
| DOID:13359 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:930) | ||||||
| Models_disease_in_annotation | WBDOannot00000133 | ||||||||
| Molecular_info | Corresponding_CDS | R10E11.4 | |||||||
| Corresponding_transcript | R10E11.4.1 | ||||||||
| Other_sequence (25) | |||||||||
| Associated_feature | WBsf651405 | ||||||||
| WBsf993801 | |||||||||
| WBsf227367 | |||||||||
| WBsf227368 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00051696 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000670 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115279 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006049 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017700 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030219 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1024395 | ||||||||
| Expr1032504 | |||||||||
| Expr1155369 | |||||||||
| Expr2016121 | |||||||||
| Expr2034356 | |||||||||
| Drives_construct | WBCnstr00035262 | ||||||||
| Construct_product | WBCnstr00035262 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (29) | |||||||||
| Map_info | Map | III | Position | 1.03005 | Error | 0.002915 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf40 | |||||||
| tnDf2 | |||||||||
| Positive_clone | C47F11 | ||||||||
| R10E11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 3138 | |||||||
| 3139 | |||||||||
| 3140 | |||||||||
| 3174 | |||||||||
| 3175 | |||||||||
| 4099 | |||||||||
| 4100 | |||||||||
| 4177 | |||||||||
| Pos_neg_data | 8494 | ||||||||
| 9447 | |||||||||
| 10530 | |||||||||
| Reference (37) | |||||||||
| Method | Gene |
