WormBase Tree Display for Gene: WBGene00005152
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| WBGene00005152 | Identity | Version | 1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | CGC_name | srf-2 | Person_evidence | WBPerson494 | |||||
| Public_name | srf-2 | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Gene_class | srf | |||||||
| Reference_allele | WBVar00275419 | ||||||||
| Allele | WBVar00275419 | Inferred_automatically | From strain object: AT6 | ||||||
| From strain object: CB6990 | |||||||||
| From strain object: JK1542 | |||||||||
| WBVar00144988 | Inferred_automatically | From strain object: CB5661 | |||||||
| WBVar02148847 | Inferred_automatically | From strain object: CB7537 | |||||||
| WBVar00144956 | |||||||||
| WBVar00144985 | |||||||||
| WBVar00144946 | |||||||||
| WBVar00145029 | |||||||||
| WBVar00142862 | |||||||||
| WBVar00000540 | |||||||||
| WBVar00142859 | |||||||||
| WBVar00145000 | |||||||||
| WBVar00144991 | |||||||||
| WBVar00144996 | |||||||||
| WBVar00144910 | |||||||||
| WBVar00142843 | |||||||||
| WBVar00142861 | |||||||||
| WBVar00145004 | |||||||||
| WBVar00142852 | |||||||||
| WBVar00142857 | |||||||||
| WBVar00054552 | |||||||||
| WBVar00054527 | |||||||||
| WBVar00275420 | |||||||||
| WBVar00142850 | |||||||||
| WBVar00142865 | |||||||||
| WBVar00144934 | |||||||||
| WBVar00144986 | |||||||||
| WBVar00142870 | |||||||||
| WBVar00142845 | |||||||||
| WBVar00054532 | |||||||||
| WBVar00144992 | |||||||||
| WBVar00054507 | |||||||||
| WBVar00054512 | |||||||||
| WBVar00000547 | |||||||||
| WBVar00142842 | |||||||||
| WBVar00275418 | |||||||||
| WBVar00142847 | |||||||||
| WBVar00142841 | |||||||||
| WBVar00142863 | |||||||||
| WBVar00142858 | |||||||||
| WBVar00142855 | |||||||||
| WBVar00142851 | |||||||||
| WBVar00142849 | |||||||||
| WBVar00144957 | |||||||||
| WBVar00144984 | |||||||||
| WBVar00054557 | |||||||||
| WBVar00142846 | |||||||||
| WBVar00142867 | |||||||||
| WBVar00142860 | |||||||||
| WBVar00144961 | |||||||||
| Legacy_information | [C.elegansII] yj262 : increased binding of anti-cuticle antiserum, ectopic lectin WGA binding, no labelling with L1-specific mAb M38. Gross morphology WT.OA>20: yj133, yj422, ct104, ct117, dv1, dv2, dv37etc. All alleles recessive. [Hemmer et al. 1991; Link et al. 1992; AT; CL] | ||||||||
| Strain | WBStrain00022558 | ||||||||
| WBStrain00000251 | |||||||||
| WBStrain00004666 | |||||||||
| WBStrain00004729 | |||||||||
| WBStrain00004768 | |||||||||
| Structured_description | Concise_description | srf-2 was identified as a mutation that alters the surface antigenicity of the cuticle in C. elegans; srf-2 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-2 mutants are resistant to infection by the nematode-specific pathogen, Microbacterium nematophilum, and do not show the tail-swelling response to infection; srf-2 mutants also show an altered response to nematophagous fungi, in the form of increased susceptibility. | Paper_evidence | WBPaper00001576 | |||||
| WBPaper00001002 | |||||||||
| WBPaper00001706 | |||||||||
| WBPaper00001280 | |||||||||
| WBPaper00004539 | |||||||||
| WBPaper00003623 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Oct 2011 00:00:00 | ||||||||
| Automated_description | Used to study bacterial infectious disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00029153 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 10 May 2023 00:00:00 | ||||||||
| Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||||
| WBPaper00029153 | |||||||||
| WBPaper00026735 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000014 | ||||||||
| Experimental_info | Expr_pattern | Expr16440 | |||||||
| Drives_construct | WBCnstr00043021 | ||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | I | Position | 5.23624 | Error | 0.183128 | |||
| Mapping_data | 2_point | 4748 | |||||||
| 4749 | |||||||||
| Multi_point | 1691 | ||||||||
| 1692 | |||||||||
| 3010 | |||||||||
| 3011 | |||||||||
| 3197 | |||||||||
| 3198 | |||||||||
| Pos_neg_data | 8076 | ||||||||
| 8088 | |||||||||
| 8096 | |||||||||
| Reference | WBPaper00001280 | ||||||||
| WBPaper00001480 | |||||||||
| WBPaper00001493 | |||||||||
| WBPaper00001576 | |||||||||
| WBPaper00001706 | |||||||||
| WBPaper00002589 | |||||||||
| WBPaper00004539 | |||||||||
| WBPaper00006215 | |||||||||
| WBPaper00010374 | |||||||||
| WBPaper00011638 | |||||||||
| WBPaper00012606 | |||||||||
| WBPaper00013879 | |||||||||
| WBPaper00014156 | |||||||||
| WBPaper00014307 | |||||||||
| WBPaper00015813 | |||||||||
| WBPaper00017907 | |||||||||
| WBPaper00018224 | |||||||||
| WBPaper00018227 | |||||||||
| WBPaper00019024 | |||||||||
| WBPaper00019027 | |||||||||
| WBPaper00019613 | |||||||||
| WBPaper00021999 | |||||||||
| WBPaper00023230 | |||||||||
| WBPaper00023275 | |||||||||
| WBPaper00025180 | |||||||||
| WBPaper00026735 | |||||||||
| WBPaper00027264 | |||||||||
| WBPaper00029153 | |||||||||
| WBPaper00029307 | |||||||||
| WBPaper00031925 | |||||||||
| WBPaper00037356 | |||||||||
| WBPaper00039104 | |||||||||
| WBPaper00048269 | |||||||||
| WBPaper00051834 | |||||||||
| WBPaper00052048 | |||||||||
| WBPaper00065106 | |||||||||
| WBPaper00065859 | |||||||||
| Method | Gene |
