WormBase Tree Display for Gene: WBGene00005643
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| WBGene00005643 | SMap | S_parent | Sequence | C05E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | srp-2 | Person_evidence | WBPerson1460 | |||||
| Sequence_name | C05E4.1 | ||||||||
| Molecular_name | C05E4.1 | ||||||||
| C05E4.1.1 | |||||||||
| CE07935 | |||||||||
| C05E4.1.2 | |||||||||
| Other_name | pes-21 | CGC_data_submission | |||||||
| CELE_C05E4.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | srp-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:38 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | srp | ||||||||
| Allele (54) | |||||||||
| Strain | WBStrain00003393 | ||||||||
| WBStrain00031378 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00029657 | ||||||||
| 00029658 | |||||||||
| 00029659 | |||||||||
| 00113762 | |||||||||
| 00113763 | |||||||||
| Ortholog (66) | |||||||||
| Paralog | WBGene00005642 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00005649 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00005647 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00005648 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00005644 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | srp-2 encodes an ovalbumin-like serpin (ov-serpin), that is a member of the serine protease inhibitor superfamily; SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00010613 | |||||||||
| WBPaper00012880 | |||||||||
| WBPaper00017560 | |||||||||
| WBPaper00041851 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Jun 2015 00:00:00 | ||||||||
| Automated_description | Enables cysteine-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular space. Expressed in several structures, including anal sphincter muscle; cuticle; epithelial cell; intestine; and phasmid neurons. Used to study familial encephalopathy with neuroserpin inclusion bodies. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Is an ortholog of human SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050831 | Homo sapiens | Paper_evidence | WBPaper00041851 | ||||
| WBPaper00046555 | |||||||||
| Accession_evidence | OMIM | 604218 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 May 2017 00:00:00 | ||||||||
| Potential_model (60) | |||||||||
| Models_disease_in_annotation | WBDOannot00000434 | ||||||||
| Models_disease_asserted | WBDOannot00000096 | ||||||||
| WBDOannot00000433 | |||||||||
| Molecular_info | Corresponding_CDS | C05E4.1 | |||||||
| Corresponding_transcript | C05E4.1.1 | ||||||||
| C05E4.1.2 | |||||||||
| Other_sequence (16) | |||||||||
| Associated_feature | WBsf646648 | ||||||||
| WBsf999209 | |||||||||
| WBsf999210 | |||||||||
| WBsf231364 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00010226 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000607 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039776 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00088978 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114476 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00000323 | ||||||||
| WBCnstr00003862 | |||||||||
| WBCnstr00015829 | |||||||||
| WBCnstr00015830 | |||||||||
| WBCnstr00021624 | |||||||||
| WBCnstr00034822 | |||||||||
| Construct_product | WBCnstr00015811 | ||||||||
| WBCnstr00015826 | |||||||||
| WBCnstr00015827 | |||||||||
| WBCnstr00015828 | |||||||||
| WBCnstr00015829 | |||||||||
| WBCnstr00015830 | |||||||||
| WBCnstr00021624 | |||||||||
| WBCnstr00034822 | |||||||||
| Antibody | WBAntibody00001646 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (178) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | V | Position | -19.954 | |||||
| Positive | Positive_clone | C05E4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4699 | |||||||
| 4700 | |||||||||
| 5348 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
