WormBase Tree Display for Gene: WBGene00006448

WBGene00006448 SMap: S_parent: Sequence: C16C10
  Identity: Version: 2
    Name: CGC_name: glod-4 Person_evidence: WBPerson4055
      Sequence_name: C16C10.10
      Molecular_name: C16C10.10
        C16C10.10.1
        CE01490
      Other_name: tag-73 Person_evidence: WBPerson201
        CELE_C16C10.10 Accession_evidence: NDB BX284603
      Public_name: glod-4
    DB_info: Database: AceView gene 3F243
        WormQTL gene WBGene00006448
        WormFlux gene WBGene00006448
        NDB locus_tag CELE_C16C10.10
        Panther gene CAEEL|WormBase=WBGene00006448|UniProtKB=Q09253
          family PTHR46466
        NCBI gene 175530
        RefSeq protein NM_065426.5
        SwissProt UniProtAcc Q09253
        TREEFAM TREEFAM_ID TF105801
        UniProt_GCRP UniProtAcc Q09253
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Jul 2007 11:50:19 WBPerson2970 Name_change: CGC_name: glod-1
                Other_name: tag-73
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: glod
    Allele (16)
    Strain: WBStrain00003573
      WBStrain00035694
    RNASeq_FPKM (74)
    GO_annotation: 00053090
      00053091
      00053092
      00053093
    Contained_in_operon: CEOP3152
    Ortholog (36)
    Structured_description: Concise_description: glod-4 encodes a glyoxalase required for normal lifespan, orthologous to human GLOD4; GLOD-4 is expressed in the larval and adult pharynx, pharyngeal-intestinal valve, intestine, anal sphincter, seam cells, amphids, and neurons, and in the adult reproductive system; overexpression of GLOD-4 increases glyoxalase activity 200-fold, reduces oxidative stress markers, and extends lifespan, probably by removing methylglyoxal from mitochondrial proteins, while glod-4(RNAi) animals exhibit increased methylglyoxalation of mitochondrial proteins and reduced lifespan; GLOD-4 activity normally decreases in vivo with age, despite unchanged levels of glod-4 mRNA. Paper_evidence: WBPaper00006525
            WBPaper00031006
            WBPaper00031464
          Curator_confirmed: WBPerson567
          Date_last_updated: 31 Mar 2008 00:00:00
      Automated_description: Involved in determination of adult lifespan and methylglyoxal metabolic process. Expressed widely. Is an ortholog of human GLOD4 (glyoxalase domain containing 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C16C10.10
    Corresponding_transcript: C16C10.10.1
    Other_sequence (52)
    Associated_feature: WBsf224687
  Experimental_info: RNAi_result (13)
    Expr_pattern: Chronogram500
      Chronogram1707
      Expr5277
      Expr8050
      Expr1018742
      Expr1032626
      Expr1144720
      Expr2012109
      Expr2030345
    Drives_construct: WBCnstr00000582
      WBCnstr00000583
      WBCnstr00004025
      WBCnstr00034352
    Construct_product: WBCnstr00034352
    Microarray_results (19)
    Expression_cluster (93)
    Interaction (15)
  Map_info: Map: III Position: -3.77504 Error: 0.009327
    Positive: Positive_clone: C16C10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4785
    Pseudo_map_position
  Reference (10)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene