WormBase Tree Display for Gene: WBGene00006474
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WBGene00006474 | SMap | S_parent | Sequence | C14B1 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | wdr | ||||||
Allele (29) | |||||||
Strain | WBStrain00032003 | ||||||
WBStrain00000041 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Contained_in_operon | CEOP3136 | ||||||
Ortholog (42) | |||||||
Paralog | WBGene00010572 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WormBase-Compara | |||||||
WBGene00013862 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
WormBase-Compara | |||||||
WBGene00012858 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00003047 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004314 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008586 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00015974 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019237 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | wdr-5.1 encodes a WD40 repeat-containing protein that is the C. elegans ortholog of mammalian WDR5, a member of a conserved H3K4 trimethylation (H3K4me3) complex; WDR-5.1 functions to regulate H3K4 methylation levels and to negatively regulate adult worm lifespan; WDR-5.1 activity also antagonizes SynMuv transcriptional repressors; WDR-5.1 is broadly expressed beginning at the 20-cell stage of embryogenesis with continuing expression seen, albeit more restricted, through adulthood; WDR-5.1 localizes to the nucleus. | Paper_evidence | WBPaper00027634 | |||
WBPaper00032309 | |||||||
WBPaper00035979 | |||||||
WBPaper00036383 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 02 Dec 2010 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in cytoplasm and nucleus. Part of MLL3/4 complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; hermaphrodite gonad; neurons; and somatic gonad precursor. Is an ortholog of human WDR5 (WD repeat domain 5). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C14B1.4 | |||||
Corresponding_transcript | C14B1.4.1 | ||||||
Other_sequence (32) | |||||||
Associated_feature | WBsf645041 | ||||||
WBsf981439 | |||||||
WBsf224640 | |||||||
WBsf224641 | |||||||
WBsf224642 | |||||||
Experimental_info | RNAi_result (18) | ||||||
Expr_pattern | Expr8345 | ||||||
Expr11955 | |||||||
Expr1019800 | |||||||
Expr1032643 | |||||||
Expr1144560 | |||||||
Expr2018057 | |||||||
Expr2036194 | |||||||
Drives_construct | WBCnstr00013269 | ||||||
WBCnstr00037899 | |||||||
Construct_product | WBCnstr00013269 | ||||||
WBCnstr00037899 | |||||||
Regulate_expr_cluster | WBPaper00045861:wdr-5(ok1417)_downregulated | ||||||
WBPaper00045861:wdr-5(ok1417)_upregulated | |||||||
WBPaper00058691:WDR-5.1_interacting_protein | |||||||
WBPaper00058711:wdr-5(ok1417)_downregulated | |||||||
WBPaper00058711:wdr-5(ok1417)_upregulated | |||||||
Microarray_results (19) | |||||||
Expression_cluster (118) | |||||||
Interaction (400) | |||||||
Map_info | Map | III | Position | -4.52761 | Error | 0.040627 | |
Positive | Positive_clone | C14B1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (31) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |