WormBase Tree Display for Gene: WBGene00006576
expand all nodes | collapse all nodes | view schema
| WBGene00006576 | SMap | S_parent | Sequence | C38C10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tkr-1 | Person_evidence | WBPerson45 | |||||
| Sequence_name | C38C10.1 | ||||||||
| Molecular_name | C38C10.1 | ||||||||
| C38C10.1.1 | |||||||||
| CE44282 | |||||||||
| Other_name | CELE_C38C10.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | tkr-1 | ||||||||
| DB_info | Database | AceView | gene | 3K479 | |||||
| WormQTL | gene | WBGene00006576 | |||||||
| WormFlux | gene | WBGene00006576 | |||||||
| NDB | locus_tag | CELE_C38C10.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006576|UniProtKB=Q03566 | |||||||
| family | PTHR46925 | ||||||||
| NCBI | gene | 192055 | |||||||
| RefSeq | protein | NM_066663.6 | |||||||
| SwissProt | UniProtAcc | Q03566 | |||||||
| UniProt_GCRP | UniProtAcc | Q03566 | |||||||
| OMIM | gene | 162332 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tkr | ||||||||
| Allele (47) | |||||||||
| Legacy_information | [C.elegansII] pk69 : Tc1 insertion, no known phenotype. Encodes predicted protein with similarity to tachykinin receptors. [NL; CGC] | ||||||||
| Strain | WBStrain00037135 | ||||||||
| WBStrain00055143 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (28) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | tkr-1 encodes a G protein-coupled receptor that is the C. elegans tachykinin-like neuropeptide receptor homolog; by homology, TKR-1 is predicted to function in modulation of excitatory neurotransmission; as loss of tkr-1 activity via RNAi results in moderate reduction of fat content, TKR-1 may play a specific role in regulating lipid metabolism; a tkr-1 reporter gene fusion is reportedly expressed in the socket cells of the deirid and post-deirid sensilla from the L2 larval stage through adulthood. | Paper_evidence | WBPaper00011028 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Oct 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable tachykinin receptor activity. Predicted to be involved in tachykinin receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in ADEsoL; ADEsoR; PDEsoL; and PDEsoR. Human ortholog(s) of this gene implicated in exercise-induced bronchoconstriction and hypogonadotropic hypogonadism 11 with or without anosmia. Is an ortholog of human TACR1 (tachykinin receptor 1) and TACR3 (tachykinin receptor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060037 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11526) | ||||
| DOID:0080821 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11526) | ||||||
| DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11526) | ||||||
| DOID:0090071 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11528) | ||||||
| Molecular_info | Corresponding_CDS | C38C10.1 | |||||||
| Corresponding_CDS_history | C38C10.1:wp209 | ||||||||
| Corresponding_transcript | C38C10.1.1 | ||||||||
| Other_sequence | ACC28554_1 | ||||||||
| JI171821.1 | |||||||||
| CJC14794_1 | |||||||||
| Acan_isotig09742 | |||||||||
| ACC21699_1 | |||||||||
| Oden_isotig16651 | |||||||||
| FC541231.1 | |||||||||
| Oden_isotig25573 | |||||||||
| FC543502.1 | |||||||||
| Oden_isotig16650 | |||||||||
| Associated_feature | WBsf993675 | ||||||||
| WBsf993676 | |||||||||
| WBsf1015601 | |||||||||
| WBsf225558 | |||||||||
| WBsf225559 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr28 | ||||||||
| Expr1011191 | |||||||||
| Expr1146132 | |||||||||
| Expr2017411 | |||||||||
| Expr2035550 | |||||||||
| Drives_construct | WBCnstr00034294 | ||||||||
| Construct_product | WBCnstr00034294 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (101) | |||||||||
| Interaction (27) | |||||||||
| Map_info | Map | III | Position | 0.457277 | Error | 0.005037 | |||
| Positive | Positive_clone | C38C10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5185 | |||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | The tyrosine-kinase genes of Tom Johnson were originally called tkr-1 and tkr-2 but have been changed to old-1 and old-2. [sdm 01.2000] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
