WormBase Tree Display for Gene: WBGene00006699
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| WBGene00006699 | Evidence | Person_evidence | WBPerson89 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C47E12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | uba-1 | Person_evidence | WBPerson89 | |||||
| Sequence_name | C47E12.5 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | spe-32 | Paper_evidence | WBPaper00032030 | ||||||
| CELE_C47E12.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | uba-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | uba | ||||||||
| Allele (68) | |||||||||
| Strain | WBStrain00033486 | ||||||||
| WBStrain00036180 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Contained_in_operon | CEOP4348 | ||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00000142 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004341 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00010882 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006700 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020184 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006735 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018357 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | uba-1 encodes the only known ubiquitin-activating enzyme in C. elegans and is orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and larval development and is required for proper formation of the male tail, sperm fertility, proper body size, meiotic progression in the embryo and germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome; experimental evidence demonstrates that uba-1 is invloved in protein ubiquitination; further, uba-1 shows synthetic lethal interactions with components of the anaphase-promoting complex (APC); a uba-1 transcriptional reporter fusion is expressed in the larval intestine. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00005337 | |||||||||
| WBPaper00032030 | |||||||||
| Person_evidence | WBPerson1119 | ||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 22 Sep 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin activating enzyme activity. Involved in several processes, including developmental process involved in reproduction; negative regulation of transcription by RNA polymerase II; and protein metabolic process. Located in nucleus. Expressed in anterior hypodermis; germ line; midbody; neurons; and pharynx. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Is an ortholog of human UBA1 (ubiquitin like modifier activating enzyme 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12469) | ||||
| DOID:0080828 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12469) | ||||||
| Molecular_info | Corresponding_CDS | C47E12.5a | |||||||
| C47E12.5b | |||||||||
| C47E12.5c | |||||||||
| Corresponding_transcript | C47E12.5a.1 | ||||||||
| C47E12.5b.1 | |||||||||
| C47E12.5b.2 | |||||||||
| C47E12.5b.3 | |||||||||
| C47E12.5b.4 | |||||||||
| C47E12.5c.1 | |||||||||
| Other_sequence (101) | |||||||||
| Associated_feature | WBsf034301 | ||||||||
| WBsf652097 | |||||||||
| WBsf652098 | |||||||||
| WBsf668196 | |||||||||
| WBsf668197 | |||||||||
| WBsf668198 | |||||||||
| WBsf668199 | |||||||||
| WBsf668200 | |||||||||
| WBsf230639 | |||||||||
| Experimental_info | RNAi_result (31) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002273 | ||||||||
| WBCnstr00012055 | |||||||||
| WBCnstr00012056 | |||||||||
| WBCnstr00034204 | |||||||||
| Construct_product | WBCnstr00014061 | ||||||||
| WBCnstr00034204 | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (164) | |||||||||
| Interaction (124) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | IV | Position | 4.46029 | Error | 0.000902 | |||
| Positive | Positive_clone | C47E12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5133 | |||||||
| Pseudo_map_position | |||||||||
| Reference (33) | |||||||||
| Remark | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb. | ||||||||
| uba-1 was mistakenly connected to C47E12.4 | Person_evidence | WBPerson89 | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
