WormBase Tree Display for Gene: WBGene00006775
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WBGene00006775 | SMap | S_parent | Sequence | F56A12 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | unc-39 | Person_evidence | WBPerson261 | |||
Sequence_name | F56A12.1 | ||||||
Molecular_name | F56A12.1 | ||||||
F56A12.1.1 | |||||||
CE37921 | |||||||
Other_name | mig-3 | ||||||
ceh-35 | Paper_evidence | WBPaper00024327 | |||||
CELE_F56A12.1 | Accession_evidence | NDB | BX284605 | ||||
Public_name | unc-39 | ||||||
DB_info | Database | AceView | gene | 5O855 | |||
WormQTL | gene | WBGene00006775 | |||||
WormFlux | gene | WBGene00006775 | |||||
OMIM | disease | 610896 | |||||
160900 | |||||||
gene | 600963 | ||||||
NDB | locus_tag | CELE_F56A12.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00006775|UniProtKB=O17894 | |||||
family | PTHR10390 | ||||||
NCBI | gene | 191623 | |||||
RefSeq | protein | NM_074162.3 | |||||
SwissProt | UniProtAcc | O17894 | |||||
UniProt_GCRP | UniProtAcc | O17894 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Acquires_merge | WBGene00000456 | ||||||
Status | Live | ||||||
Gene_info (11) | |||||||
Disease_info | Experimental_model | DOID:11722 | Homo sapiens | Paper_evidence | WBPaper00024327 | ||
Accession_evidence | OMIM | 160900 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 24 Oct 2013 00:00:00 | ||||||
DOID:14702 | Homo sapiens | Paper_evidence | WBPaper00024327 | ||||
Accession_evidence | OMIM | 610896 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 24 Oct 2013 00:00:00 | ||||||
Potential_model | DOID:0111424 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10891) | |||
Disease_relevance | Mutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy. | Homo sapiens | Paper_evidence | WBPaper00024327 | |||
Accession_evidence | OMIM | 600963 | |||||
160900 | |||||||
610896 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 01 May 2014 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000238 | ||||||
WBDOannot00000299 | |||||||
Molecular_info | Corresponding_CDS | F56A12.1 | |||||
Corresponding_CDS_history | F56A12.1:wp137 | ||||||
Corresponding_transcript | F56A12.1.1 | ||||||
Other_sequence | Acan_isotig06578 | ||||||
Dviv_isotig15575 | |||||||
Dviv_isotig15576 | |||||||
Acan_isotig06577 | |||||||
Oden_isotig18067 | |||||||
Tcir_isotig25512 | |||||||
Oden_isotig25907 | |||||||
JI463737.1 | |||||||
Oden_isotig18066 | |||||||
JI211494.1 | |||||||
Associated_feature | WBsf647528 | ||||||
WBsf662081 | |||||||
WBsf662082 | |||||||
WBsf662083 | |||||||
WBsf978863 | |||||||
WBsf1001995 | |||||||
WBsf1020832 | |||||||
WBsf232919 | |||||||
WBsf232920 | |||||||
Gene_product_binds (218) | |||||||
Transcription_factor | WBTranscriptionFactor000219 | ||||||
Experimental_info | RNAi_result | WBRNAi00101784 | Inferred_automatically | RNAi_primary | |||
WBRNAi00032912 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089718 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090158 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090317 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00061182 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00015762 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00048581 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00114716 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089999 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00004349 | ||||||
WBCnstr00011130 | |||||||
WBCnstr00012730 | |||||||
WBCnstr00015880 | |||||||
WBCnstr00016522 | |||||||
WBCnstr00034159 | |||||||
Construct_product | WBCnstr00011130 | ||||||
WBCnstr00015880 | |||||||
WBCnstr00016701 | |||||||
WBCnstr00034159 | |||||||
Regulate_expr_cluster | WBPaper00050496:unc-39(hp701)_regulated | ||||||
Microarray_results (20) | |||||||
Expression_cluster (153) | |||||||
Interaction (134) | |||||||
Map_info | Map | V | Position | 6.28117 | Error | 0.001023 | |
Positive | Positive_clone | F56A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data (3) | |||||||
Reference (35) | |||||||
Method | Gene |