WormBase Tree Display for Gene: WBGene00006875
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WBGene00006875 | Evidence | Paper_evidence | WBPaper00005969 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T22C8 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | vab | ||||||
Reference_allele | WBVar00144274 | ||||||
Allele (27) | |||||||
Legacy_information | e1744 : slightly dumpy tail whip knobbed at all stages except adult male (adult male tail tip slightly swollen); variably Egl. ES3 (larvae) ME2. NA3 (e1775 e2016 : resemble e1744 slightly dumpier). | ||||||
See also e1744, e1775, e2016 | |||||||
[C.elegansII] e1744 : slightly dumpy, tail whip knobbed at all stages except adult male (adult male tail tip slightly swollen); variably Egl. ES3 (larvae) ME2. OA2: e1775, e2016 (resemble e1744, slightly dumpier). [Hodgkin 1974] | |||||||
Strain | WBStrain00004468 | ||||||
WBStrain00007740 | |||||||
WBStrain00007742 | |||||||
WBStrain00007743 | |||||||
WBStrain00031259 | |||||||
WBStrain00031254 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (10) | |||||||
Ortholog (38) | |||||||
Structured_description | Concise_description | vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization. | Paper_evidence | WBPaper00000608 | |||
WBPaper00004961 | |||||||
WBPaper00005946 | |||||||
WBPaper00005969 | |||||||
WBPaper00005975 | |||||||
WBPaper00012856 | |||||||
WBPaper00012883 | |||||||
WBPaper00018356 | |||||||
Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson13481 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Involved in cell-cell adhesion; defense response to Gram-negative bacterium; and innate immune response. Located in cell junction. Expressed in epithelial cell; hypodermis; and nerve ring. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Is an ortholog of human TMEM47 (transmembrane protein 47). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0112011 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17637) | ||
DOID:0050467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17637) | ||||
Molecular_info | Corresponding_CDS | T22C8.8 | |||||
Corresponding_CDS_history | T22C8.8:wp92 | ||||||
Corresponding_transcript | T22C8.8.1 | ||||||
Other_sequence (22) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result | WBRNAi00073283 | Inferred_automatically | RNAi_primary | |||
WBRNAi00019018 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00065106 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092872 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00035805 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00053821 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2609 | ||||||
Expr2610 | |||||||
Expr1021012 | |||||||
Expr1032915 | |||||||
Expr1157368 | |||||||
Expr2017954 | |||||||
Expr2036090 | |||||||
Drives_construct | WBCnstr00000672 | ||||||
WBCnstr00034116 | |||||||
Construct_product | WBCnstr00034116 | ||||||
Antibody | WBAntibody00000653 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (142) | |||||||
Interaction (27) | |||||||
Map_info | Map | II | Position | 0.829738 | Error | 0.001028 | |
Well_ordered | |||||||
Positive | Inside_rearr | mnDf63 | |||||
mnDf68 | |||||||
mnDf69 | |||||||
Positive_clone | T22C8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Mapping_data | 2_point | 620 | |||||
626 | |||||||
Multi_point (13) | |||||||
Pos_neg_data (17) | |||||||
Reference (38) | |||||||
Method | Gene |