WormBase Tree Display for Gene: WBGene00006881

WBGene00006881 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: R07B1
  Identity: Version: 1
    Name: CGC_name: vab-15 Person_evidence: WBPerson261
      Sequence_name: R07B1.1
      Molecular_name: R07B1.1
        R07B1.1.1
        CE01626
      Other_name: CELE_R07B1.1 Accession_evidence: NDB BX284606
      Public_name: vab-15
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vab
    Allele (45)
    Legacy_information: [Du H, Chalfie M ] u781 recessive; homozygotes exhibit multiple defects: absence of AVM, PVM, PLM, abnormal ALM migrations, variable morphological defects, 66% lethal at embryonic or larval stages; Mec; Tab; Unc; Egl. Cloned: vab-15 is R07B1.1, encoding msh-type homeoprotein. u781 affects splice donor in second intron.
    Complementation_data: [Du H, Chalfie M ] complements unc-58, unc-115
    Strain: WBStrain00035305
      WBStrain00035047
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (45)
    Structured_description: Concise_description: The vab-15 gene is similar to the msh (muscle segment homeobox) class of homeobox genes that occur both in invertebrates, and in vertebrates including humans, where they are called Msx genes; vab-15 is required for the proper differentiation of touch neurons, axon guidance and embryonic viability; vab-15 is mostly expressed in embryos and young larvae and localizes to the nucleus. Paper_evidence: WBPaper00004685
            WBPaper00026621
          Curator_confirmed: WBPerson324
          Date_last_updated: 30 Sep 2011 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic morphogenesis; locomotory behavior; and parturition. Located in nucleus. Expressed in several structures, including P1; P12; P2; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including cleft lip; orofacial cleft 5; and tooth disease (multiple). Is an ortholog of human MSX1 (msh homeobox 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:13714 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7391)
      DOID:0080399 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7391)
      DOID:6678 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7391)
      DOID:9296 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7391)
      DOID:2340 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7392)
      DOID:0060285 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7392)
      DOID:0050591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7391)
      DOID:674 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7391)
    Disease_relevance: The vab-15 gene encodes a msh-like homeodomain protein and is orthologous with human msh homeobox 1 (MSX1); homeodomain proteins act early during developmental processes to control the formation of several body structures; mutations in human MSX1 are associated with developmental disorders of oral structures like the teeth and mouth, these disorders include Orofacial cleft, Tooth agenesis and Wiktop syndrome; in C. elegans vab-15 is required for embryonic viability, formation of the touch cells and proper navigation of neurons. Homo sapiens Paper_evidence: WBPaper00004685
            WBPaper00026621
          Accession_evidence: OMIM 142983
          Curator_confirmed: WBPerson324
          Date_last_updated: 30 Sep 2011 00:00:00
  Molecular_info: Corresponding_CDS: R07B1.1
    Corresponding_transcript: R07B1.1.1
    Other_sequence: JI180574.1
      TSC11261_1
      EX501502.1
      Oden_isotig20474
      JI179004.1
      JI180736.1
    Associated_feature (12)
    Transcription_factor: WBTranscriptionFactor000592
  Experimental_info: RNAi_result: WBRNAi00051409 Inferred_automatically: RNAi_primary
      WBRNAi00026050 Inferred_automatically: RNAi_primary
      WBRNAi00026049 Inferred_automatically: RNAi_primary
      WBRNAi00085757 Inferred_automatically: RNAi_primary
      WBRNAi00027432 Inferred_automatically: RNAi_primary
      WBRNAi00034674 Inferred_automatically: RNAi_primary
      WBRNAi00000891 Inferred_automatically: RNAi_primary
      WBRNAi00017499 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram141
      Expr1359
      Expr7632
      Expr13282
      Expr15645
      Expr1022287
      Expr1032917
      Expr1155096
      Expr2017946
      Expr2036082
    Drives_construct: WBCnstr00001115
      WBCnstr00010233
      WBCnstr00012777
      WBCnstr00034115
    Construct_product: WBCnstr00034115
      WBCnstr00038854
    Microarray_results (21)
    Expression_cluster (117)
    Interaction (262)
  Map_info: Map: X Position: 1.72569 Error: 0.00205
    Well_ordered
    Positive: Positive_clone: R07B1 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4018
      Pos_neg_data: 10644
  Reference (15)
  Remark: Data extracted from Du and Chalfie (2001)
  Method: Gene