WormBase Tree Display for Gene: WBGene00006920
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| WBGene00006920 | SMap | S_parent | Sequence | Y38F2AL | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vha-11 | |||||||
| Sequence_name | Y38F2AL.3 | ||||||||
| Molecular_name | Y38F2AL.3a | ||||||||
| Y38F2AL.3a.1 | |||||||||
| CE29997 | |||||||||
| Y38F2AL.3b | |||||||||
| CE38743 | |||||||||
| Y38F2AL.3b.1 | |||||||||
| Other_name | CELE_Y38F2AL.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | vha-11 | ||||||||
| DB_info | Database | AceView | gene | 4D74 | |||||
| WormQTL | gene | WBGene00006920 | |||||||
| WormFlux | gene | WBGene00006920 | |||||||
| NDB | locus_tag | CELE_Y38F2AL.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006920|UniProtKB=Q9XXU9 | |||||||
| family | PTHR10137 | ||||||||
| NCBI | gene | 177017 | |||||||
| RefSeq | protein | NM_001380087.1 | |||||||
| NM_001028280.6 | |||||||||
| SwissProt | UniProtAcc | Q9XXU9 | |||||||
| TREEFAM | TREEFAM_ID | TF314912 | |||||||
| UniProt_GCRP | UniProtAcc | Q9XXU9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vha | ||||||||
| Allele (152) | |||||||||
| Strain | WBStrain00049354 | ||||||||
| WBStrain00051762 | |||||||||
| WBStrain00051767 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP4638 | ||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | vha-11 encodes, by alternative splicing, two isoforms of an ortholog ofsubunit C of the cytoplasmic (V1) domain of vacuolarproton-translocating ATPase (V-ATPase); VHA-11 is a predicted cytosolicstator (stalk) component; VHA-11 is found in dot-like structures aroundembryonic nuclei, with diffuse distribution in embryonic cytoplasm; inlater embryos (comma stage onward), VHA-11 is found in gut granules (atype of lysosome, expected to require acidification); VHA-11 ispredominantly expressed in the excretory cell and in intestinal cells inthe adult; VHA-11 is required for ovulation and embryogenesis, sincevha-11(RNAi) animals are sterile with polyploid, unmatured oocytes anddead progeny; VHA-11 is also required for normal formation of gutgranules, since vha-11(RNAi) embryonic intestines fail to stain withacridine orange; glo-1 mutant intestines fail to show punctate VHA-11;vha-11 shares an operon with vha-3; transgenic vha-11 complements anull mutation of its S. cerevisiae ortholog, VMA5. | Paper_evidence | WBPaper00003195 | |||||
| WBPaper00004341 | |||||||||
| WBPaper00025094 | |||||||||
| WBPaper00028773 | |||||||||
| WBPaper00028774 | |||||||||
| WBPaper00028775 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development and ovulation. Predicted to be located in cytoplasm and membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Expressed in excretory cell; hypodermis; and intestinal cell. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma and stomach carcinoma. Is an ortholog of human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:856) | ||||
| DOID:5517 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:856) | ||||||
| Molecular_info | Corresponding_CDS | Y38F2AL.3a | |||||||
| Y38F2AL.3b | |||||||||
| Corresponding_CDS_history | Y38F2AL.3b:wp144 | ||||||||
| Corresponding_transcript | Y38F2AL.3a.1 | ||||||||
| Y38F2AL.3b.1 | |||||||||
| Other_sequence (125) | |||||||||
| Associated_feature | WBsf667772 | ||||||||
| WBsf667773 | |||||||||
| WBsf981687 | |||||||||
| WBsf995658 | |||||||||
| WBsf995659 | |||||||||
| WBsf995660 | |||||||||
| WBsf1016884 | |||||||||
| WBsf229803 | |||||||||
| WBsf229804 | |||||||||
| WBsf229805 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr951 | ||||||||
| Expr1401 | |||||||||
| Expr1013583 | |||||||||
| Expr1032937 | |||||||||
| Expr1159566 | |||||||||
| Expr2017977 | |||||||||
| Expr2036113 | |||||||||
| Drives_construct | WBCnstr00010261 | ||||||||
| Antibody | WBAntibody00000315 | ||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (172) | |||||||||
| Interaction (53) | |||||||||
| Map_info | Map | IV | Position | -8.18629 | Error | 0.045922 | |||
| Positive | Positive_clone | Y38F2AL | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
