WormBase Tree Display for Gene: WBGene00006958
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| WBGene00006958 | Evidence | Paper_evidence | WBPaper00005843 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CGC_data_submission | |||||||||
| SMap | S_parent | Sequence | R06C1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | wve-1 | Person_evidence | WBPerson633 | |||||
| Sequence_name | R06C1.3 | ||||||||
| Molecular_name | R06C1.3a | ||||||||
| R06C1.3a.1 | |||||||||
| CE36188 | |||||||||
| R06C1.3b | |||||||||
| CE45993 | |||||||||
| R06C1.3b.1 | |||||||||
| Other_name | gex-1 | Person_evidence | WBPerson608 | ||||||
| CELE_R06C1.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | wve-1 | ||||||||
| DB_info | Database | AceView | gene | 1M516 | |||||
| WormQTL | gene | WBGene00006958 | |||||||
| WormFlux | gene | WBGene00006958 | |||||||
| NDB | locus_tag | CELE_R06C1.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006958|UniProtKB=Q9XVK6 | |||||||
| family | PTHR12902 | ||||||||
| NCBI | gene | 187639 | |||||||
| RefSeq | protein | NM_001264833.3 | |||||||
| NM_001392954.1 | |||||||||
| TREEFAM | TREEFAM_ID | TF315031 | |||||||
| TrEMBL | UniProtAcc | F5GUF0 | |||||||
| Q9XVK6 | |||||||||
| UniProt_GCRP | UniProtAcc | Q9XVK6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wve | ||||||||
| Allele (96) | |||||||||
| Legacy_information | gex-1 animals are Egl Mels. The maternal effect lethal phenotype leads to embryos in which epidermal cells fail to migrate, leading to the Gex (gut on the exterior) phenotype. Zygotic defects include a highly penetrant egg-laying defect, although they have wildtype-looking L3/L4 vulvae | Person_evidence | WBPerson608 | ||||||
| Strain | WBStrain00037507 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Contained_in_operon | CEOP1660 | ||||||||
| Ortholog (45) | |||||||||
| Structured_description | Concise_description | wve-1 encodes a homolog of the mammalian WAVE protein; based on homology WVE-1 might be involved in actin cytoskeletal dynamics; wve-1 is required for early cell migrations in the epidermis during embryonic morphogenesis and may require gex-2 and gex-3 for its function. | Paper_evidence | WBPaper00005843 | |||||
| WBPaper00018742 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in several processes, including generation of neurons; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of SCAR complex. Expressed in Q cell and anchor cell. Is an ortholog of human WASF1 (WASP family member 1); WASF2 (WASP family member 2); and WASF3 (WASP family member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R06C1.3a | |||||||
| R06C1.3b | |||||||||
| Corresponding_CDS_history | R06C1.3:wp114 | ||||||||
| Corresponding_transcript | R06C1.3a.1 | ||||||||
| R06C1.3b.1 | |||||||||
| Other_sequence | Dviv_isotig22443 | ||||||||
| CJC03910_1 | |||||||||
| SRC00490_1 | |||||||||
| FC810013.1 | |||||||||
| FC815385.1 | |||||||||
| Associated_feature | WBsf665012 | ||||||||
| WBsf985416 | |||||||||
| WBsf985417 | |||||||||
| WBsf985418 | |||||||||
| WBsf1010808 | |||||||||
| Experimental_info | RNAi_result (41) | ||||||||
| Expr_pattern | Expr8395 | ||||||||
| Expr13652 | |||||||||
| Expr13967 | |||||||||
| Expr1024563 | |||||||||
| Expr1032969 | |||||||||
| Expr1155069 | |||||||||
| Expr2018087 | |||||||||
| Expr2036225 | |||||||||
| Drives_construct | WBCnstr00013296 | ||||||||
| Construct_product | WBCnstr00005344 | ||||||||
| WBCnstr00013296 | |||||||||
| WBCnstr00014897 | |||||||||
| WBCnstr00042921 | |||||||||
| Antibody | WBAntibody00001477 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (92) | |||||||||
| Interaction (93) | |||||||||
| Map_info | Map | I | Position | 13.0101 | Error | 0.001164 | |||
| Positive | Positive_clone | R06C1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (43) | |||||||||
| Remark | [Priess J] Map IR. not cloned | ||||||||
| We cloned wve-1 (gex-1) and found mutations in the R06C1.3 gene in our two alleles. WVE-1 appears to be the C. elegans homolog of proteins named WAVE and SCAR in other systems. | Person_evidence | WBPerson608 | |||||||
| gex-1 has been renamed to wve-1 [030331 ck1] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
