WormBase Tree Display for Gene: WBGene00007009

WBGene00007009 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y65B4BR
  Identity: Version: 1
    Name: CGC_name: wwp-1 Person_evidence: WBPerson220
      Sequence_name: Y65B4BR.4
      Molecular_name (12)
      Other_name: CeWWP1
        Y65B4B_11.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y65B4BR.4 Accession_evidence: NDB BX284601
      Public_name: wwp-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 10 May 2004 10:27:58 WBPerson1845 Event: Created
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: wwp
    Allele (86)
    Strain: WBStrain00003437
      WBStrain00031879
      WBStrain00036151
      WBStrain00051079
      WBStrain00036181
    RNASeq_FPKM (74)
    GO_annotation (31)
    Contained_in_operon: CEOP1934
    Ortholog (45)
    Paralog: WBGene00022069 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009738 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022358 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003898 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008429 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009460 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016405 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017782 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021685 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: wwp-1 encodes, by alternative splicing, two isoforms of a putative E3 ubiquitin ligase orthologous to budding yeast Rsp5, Drosophila SU(DX), and human WWP1 (OMIM:602307) and WWP2 (OMIM:602308); WWP-1 is required for proteolysis of the intracellular LIN-12 domain in primary ventral precursor cells, and for protection of germ cells against ionizing radiation or camptothecin, as well as for normal acetylcholine neurotransmission, axonal guidance and fasciculation, patterning of the ventral nerve cord, locomotion, fat content, and late embryonic morphogenesis; in UV-irradiated nondauer larvae, WWP-1 stimulates the proteolysis of AMA-1; although WWP-1's is normally blocked from fully activating AMA-1 proteolysis by XPA-1/RAD-3, it also cooperates with XPA-1/RAD-3 to protect worms from UV-irradiation; WWP-1 is expressed in many neurons (cholinergic and GABAergic motor neurons, head, tail, body, and nerve cords), in larval and adult pharynx, intestine, renal gland cells and rectal epithelium, and in adult vulval muscle, body wall muscle, and coelomocytes; WWP-1 contains an N-terminal C2 domain, four central WW repeats and a C-terminal HECT ubiquitin ligase domain; WWP-1 binds UBC-18 in yeast two-hybrid assays, but is not required for UBC-18's activity in pharyngeal development. Paper_evidence (13)
          Curator_confirmed: WBPerson567
          Date_last_updated: 09 Mar 2008 00:00:00
      Automated_description: Enables ubiquitin conjugating enzyme activity. Involved in defense response to bacterium; protein ubiquitination; and regulation of protein catabolic process. Acts upstream of or within determination of adult lifespan. Located in cytoplasm. Expressed in GABAergic neurons; cholinergic neurons; coelomocyte; somatic neurons; and vulval muscle. Is an ortholog of human WWP1 (WW domain containing E3 ubiquitin protein ligase 1) and WWP2 (WW domain containing E3 ubiquitin protein ligase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y65B4BR.4a
      Y65B4BR.4b
      Y65B4BR.4c
      Y65B4BR.4d
    Corresponding_transcript: Y65B4BR.4a.1
      Y65B4BR.4b.1
      Y65B4BR.4c.1
      Y65B4BR.4d.1
    Other_sequence (94)
    Associated_feature: WBsf643021
      WBsf655854
      WBsf655855
      WBsf655856
      WBsf655857
      WBsf655858
      WBsf980930
      WBsf982531
      WBsf982532
      WBsf217143
  Experimental_info: RNAi_result (51)
    Expr_pattern: Expr3542
      Expr3579
      Expr7091
      Expr1014995
      Expr1032999
      Expr1161348
      Expr2018088
      Expr2036226
    Drives_construct: WBCnstr00003900
      WBCnstr00011466
      WBCnstr00034041
    Construct_product: WBCnstr00011503
      WBCnstr00034041
    Microarray_results (31)
    Expression_cluster (90)
    Interaction (171)
  Map_info: Map: I Position: -18.9571 Error: 0.003413
    Positive: Positive_clone: Y65B4BR Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5001
        4391
    Pseudo_map_position
  Reference (29)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene