WormBase Tree Display for Gene: WBGene00007010
expand all nodes | collapse all nodes | view schema
| WBGene00007010 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | R10E12 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | alx-1 | Person_evidence | WBPerson220 | |||||
| Sequence_name | R10E12.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | pqn-58 | CGC_data_submission | |||||||
| YNK1 | |||||||||
| CELE_R10E12.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | alx-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 10 May 2004 11:58:09 | WBPerson1845 | Event | Created | |||
| 2 | 18 May 2004 10:42:46 | WBPerson1845 | Event | Acquires_merge | WBGene00004142 | ||||
| Acquires_merge | WBGene00004142 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | alx | ||||||||
| Allele (77) | |||||||||
| Strain | WBStrain00033317 | ||||||||
| WBStrain00035867 | |||||||||
| WBStrain00036111 | |||||||||
| WBStrain00036160 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00001215 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| Structured_description | Concise_description | alx-1 encodes one of two C. elegans Bro1 domain-containing proteins; during development, ALX-1 functions in the regulation of protein trafficking via endocytic recycling of clathrin-independent cargo and membrane-protein degradation; ALX-1 physically interacts with RME-1, a component of recycling endosomes that regulates endocytic recycling of receptor proteins, and LIN-12/Notch whose downregulation, but not internalization, in primary vulval precursor cells requires ALX-1; alx-1 interacts genetically with ego-2, which encodes the second C. elegans Bro1 domain-containing protein, in a manner that suggests ALX-1 and EGO-2 function both agonistically and antagostically to regulate specific developmental processes; an ALX-1::GFP fusion protein is expressed ubiquitously at high levels and localizes to two types of endocytic organelles: the HGRS-1-positive multivesicular endosome and the RME-1-positive recycling endosome. | Paper_evidence | WBPaper00026869 | |||||
| WBPaper00030823 | |||||||||
| WBPaper00031193 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 23 Jun 2008 00:00:00 | ||||||||
| Automated_description | Enables Notch binding activity. Involved in cellular localization; endosome organization; and regulation of protein catabolic process. Located in basolateral plasma membrane; multivesicular body; and recycling endosome. Expressed in several structures, including vulva. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human PDCD6IP (programmed cell death 6 interacting protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8766) | ||||
| Molecular_info | Corresponding_CDS | R10E12.1a | |||||||
| R10E12.1b | |||||||||
| R10E12.1c | |||||||||
| R10E12.1d | |||||||||
| Corresponding_transcript | R10E12.1a.1 | ||||||||
| R10E12.1b.1 | |||||||||
| R10E12.1c.1 | |||||||||
| R10E12.1d.1 | |||||||||
| Other_sequence (56) | |||||||||
| Associated_feature | WBsf993860 | ||||||||
| WBsf993861 | |||||||||
| WBsf1015702 | |||||||||
| WBsf225651 | |||||||||
| WBsf225652 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00017704 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00051704 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069914 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034819 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006063 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3737 | ||||||||
| Expr7809 | |||||||||
| Expr16155 | |||||||||
| Expr1028721 | |||||||||
| Expr1033000 | |||||||||
| Expr1155375 | |||||||||
| Expr2009315 | |||||||||
| Expr2027551 | |||||||||
| Drives_construct | WBCnstr00001769 | ||||||||
| WBCnstr00011641 | |||||||||
| WBCnstr00034040 | |||||||||
| Construct_product | WBCnstr00001769 | ||||||||
| WBCnstr00001819 | |||||||||
| WBCnstr00001820 | |||||||||
| WBCnstr00001821 | |||||||||
| WBCnstr00001823 | |||||||||
| WBCnstr00011641 | |||||||||
| WBCnstr00034040 | |||||||||
| Antibody | WBAntibody00001820 | ||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (102) | |||||||||
| Map_info | Map | III | Position | 1.44906 | Error | 0.029014 | |||
| Positive | Positive_clone | R10E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4633 | |||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
