WormBase Tree Display for Gene: WBGene00007029
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WBGene00007029 | Evidence | Paper_evidence | WBPaper00013412 | |||||
---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | VC5 | |||||
Identity | Version | 1 | ||||||
Name | CGC_name | mys-1 | Person_evidence | WBPerson268 | ||||
Sequence_name | VC5.4 | |||||||
Molecular_name | VC5.4 | |||||||
VC5.4.1 | ||||||||
CE21225 | ||||||||
Other_name | CELE_VC5.4 | Accession_evidence | NDB | BX284605 | ||||
Public_name | mys-1 | |||||||
DB_info | Database (12) | |||||||
Species | Caenorhabditis elegans | |||||||
History | Version_change | 1 | 19 May 2004 10:53:51 | WBPerson1845 | Event | Created | ||
Status | Live | |||||||
Gene_info | Biotype | SO:0001217 | ||||||
Gene_class | mys | |||||||
Allele (46) | ||||||||
Strain | WBStrain00027398 | |||||||
WBStrain00027425 | ||||||||
RNASeq_FPKM (74) | ||||||||
GO_annotation (26) | ||||||||
Ortholog (47) | ||||||||
Paralog | WBGene00016200 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | ||||||||
WBGene00007914 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | ||||||||
WBGene00018013 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | ||||||||
WBGene00045419 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | ||||||||
WBGene00010537 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
Structured_description | Concise_description | mys-1 encodes a MYST family histone acetyltransferase orthologous to Drosophila EG0007.7, human TIP60, and S. cerevisiae Esa1p; during vulval development, mys-1 acts as Class C synMuv gene: mys-1 mutations enhance mutations in components of the C. elegans NuRD and Rb repressor complexes that negatively regulate expression of genes required for vulval induction; in addition, mys-1(RNAi) enhances mutations in pha-4, which encodes a FoxA transcription factor required for pharyngeal organogenesis; mys-1 mutations also cause a synthetic slow growth phenotype in combination with mutations in the MCD-1 zinc-finger protein; thus, mys-1 activity is essential for proper cell fate specification of different cell types at different times during C. elegans development. | Paper_evidence | WBPaper00004587 | ||||
WBPaper00013412 | ||||||||
WBPaper00028549 | ||||||||
WBPaper00029005 | ||||||||
Curator_confirmed | WBPerson1843 | |||||||
WBPerson567 | ||||||||
Date_last_updated | 17 Jul 2007 00:00:00 | |||||||
Automated_description | Predicted to enable histone H4K16 acetyltransferase activity and transcription coregulator activity. Involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of cell fate specification; and protein localization to chromatin. Predicted to be located in nucleus. Predicted to be part of MSL complex. Used to study obesity. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human KAT5 (lysine acetyltransferase 5). | Paper_evidence | WBPaper00065943 | |||||
Curator_confirmed | WBPerson324 | |||||||
WBPerson37462 | ||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||||
Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | |||
Curator_confirmed | WBPerson324 | |||||||
Date_last_updated | 28 Jun 2022 00:00:00 | |||||||
Potential_model | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5275) | ||||
Models_disease_in_annotation | WBDOannot00001260 | |||||||
Molecular_info | Corresponding_CDS | VC5.4 | ||||||
Corresponding_transcript | VC5.4.1 | |||||||
Other_sequence (44) | ||||||||
Associated_feature | WBsf652755 | |||||||
WBsf1000424 | ||||||||
WBsf1019894 | ||||||||
WBsf233902 | ||||||||
Experimental_info | RNAi_result (49) | |||||||
Expr_pattern | Expr1014984 | |||||||
Expr1033018 | ||||||||
Expr1158008 | ||||||||
Expr2013848 | ||||||||
Expr2032088 | ||||||||
Regulate_expr_cluster | WBPaper00050370:mys-1(RNAi)_L3_downregulated | |||||||
WBPaper00050370:mys-1(RNAi)_L3_upregulated | ||||||||
WBPaper00064735:mys-1(RNAi)_vs_N2_downregulated | ||||||||
WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated | ||||||||
Antibody | WBAntibody00002720 | |||||||
Microarray_results (19) | ||||||||
Expression_cluster (99) | ||||||||
Interaction (197) | ||||||||
WBProcess | WBbiopr:00000071 | |||||||
WBbiopr:00000072 | ||||||||
WBbiopr:00000073 | ||||||||
Map_info | Map | V | Position | 0.546651 | Error | 0.006496 | ||
Positive | Positive_clone | VC5 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Mapping_data | Multi_point | 4911 | ||||||
Pseudo_map_position | ||||||||
Reference (36) | ||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |