WormBase Tree Display for Gene: WBGene00008419
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WBGene00008419 | SMap | S_parent | Sequence | D2030 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | wdr-23 | Person_evidence | WBPerson590 | |||
Sequence_name | D2030.9 | ||||||
Molecular_name (16) | |||||||
Other_name | xrep-1 | Paper_evidence | WBPaper00036411 | ||||
Person_evidence | WBPerson1284 | ||||||
CELE_D2030.9 | Accession_evidence | NDB | BX284601 | ||||
Public_name | wdr-23 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | wdr | ||||||
Allele (92) | |||||||
Strain | WBStrain00001583 | ||||||
WBStrain00001735 | |||||||
WBStrain00005859 | |||||||
WBStrain00005861 | |||||||
WBStrain00055405 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (26) | |||||||
Contained_in_operon | CEOP1408 | ||||||
Ortholog (33) | |||||||
Structured_description | Concise_description | wdr-23 encodes a WD40 repeat-containing protein; WDR-23 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that negatively regulates accumulation and hence, transcriptional activation activity of the SKN-1 transcription factor in intestinal nuclei; wdr-23 activity is thus required for regulation of stress resistance, longevity, and normal growth and development; WDR-23 physically interacts with DDB-1 and SKN-1, thus likely serving as a bridge between the ubiquitin ligase complex and its SKN-1 substrate; in regulating skn-1 function, wdr-23 appears to act downstream of the p38 MAPK pathway and together with gsk-3 and the daf-2-mediated insulin signaling pathway; WDR-23 is expressed in the intestine, hypodermis, and neurons, where it localizes to nuclei. | Paper_evidence | WBPaper00032980 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 06 Apr 2010 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including intracellular membrane-bounded organelle; neuronal cell body; and striated muscle dense body. Expressed in ASIL; ASIR; head; muscle cell; and tail. Is an ortholog of human DCAF11 (DDB1 and CUL4 associated factor 11). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | D2030.9a | |||||
D2030.9b | |||||||
D2030.9c | |||||||
D2030.9d | |||||||
D2030.9e | |||||||
Corresponding_transcript | D2030.9a.1 | ||||||
D2030.9a.2 | |||||||
D2030.9b.1 | |||||||
D2030.9c.1 | |||||||
D2030.9d.1 | |||||||
D2030.9e.1 | |||||||
Other_sequence (26) | |||||||
Associated_feature (17) | |||||||
Experimental_info | RNAi_result (54) | ||||||
Expr_pattern (17) | |||||||
Drives_construct (12) | |||||||
Construct_product (14) | |||||||
Regulate_expr_cluster | WBPaper00042215:wdr-23(tm1817)_downregulated | ||||||
WBPaper00042215:wdr-23(tm1817)_upregulated | |||||||
WBPaper00044743:wdr-23_neuron_upregulated | |||||||
WBPaper00059566:wdr-23(mac32)_downregulated | |||||||
WBPaper00059566:wdr-23(mac32)_upregulated | |||||||
Microarray_results (40) | |||||||
Expression_cluster (155) | |||||||
Interaction (42) | |||||||
Map_info | Map | I | Position | 2.19591 | Error | 0.005029 | |
Positive | Positive_clone | D2030 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (48) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |