WormBase Tree Display for Gene: WBGene00008719

WBGene00008719 SMap: S_parent: Sequence: F11F1
  Identity: Version: 2
    Name: CGC_name: ttr-52
      Sequence_name: F11F1.7
      Molecular_name: F11F1.7
        F11F1.7.1
        CE47922
      Other_name: CELE_F11F1.7 Accession_evidence: NDB BX284603
      Public_name: ttr-52
    DB_info: Database: AceView gene 3O495
        WormQTL gene WBGene00008719
        WormFlux gene WBGene00008719
        NDB locus_tag CELE_F11F1.7
        Panther gene CAEEL|WormBase=WBGene00008719|UniProtKB=G5ED35
          family PTHR21700
        NCBI gene 184363
        RefSeq protein NM_001392229.1
        SwissProt UniProtAcc G5ED35
        TREEFAM TREEFAM_ID TF318551
        UniProt_GCRP UniProtAcc G5ED35
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Sep 2007 11:48:01 WBPerson2970 Name_change: CGC_name: ttr-52
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ttr
    Allele (17)
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (21)
    Paralog (62)
    Structured_description: Concise_description: ttr-52 encodes a transthyretin-like secreted protein that is required for proper cell corpse engulfment; genetic analysis indicates that ttr-52 functions in the ced-1/CD91 pathway for engulfment; TTR-52 binds to both surface-exposed phosphatidylserine in vivo and the extracellular domain of CED-1, therefore acting like a bridging molecule during the recognition of apoptotic cells during cell corpse engulfment; ttr-52 is expressed in, and secreted from intestinal cells and co-localizes to apoptotic cells together with CED-1. Paper_evidence: WBPaper00036352
          Curator_confirmed: WBPerson324
          Date_last_updated: 07 Sep 2011 00:00:00
      Automated_description: Enables several functions, including phosphatidylserine binding activity; protein homodimerization activity; and scavenger receptor binding activity. Involved in aminophospholipid transport; apoptotic process involved in development; and recognition of apoptotic cell. Located in cell surface and extracellular vesicle. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F11F1.7
    Corresponding_CDS_history: F11F1.7:wp179
      F11F1.7a:wp237
    Corresponding_transcript: F11F1.7.1
    Other_sequence: PPC09663_1
      PP01855
      Acan_isotig13716
      JI181978.1
      PPC01298_1
    Associated_feature: WBsf645711
      WBsf994880
      WBsf226004
  Experimental_info: RNAi_result: WBRNAi00044403 Inferred_automatically: RNAi_primary
      WBRNAi00006115 Inferred_automatically: RNAi_primary
      WBRNAi00030834 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9060
      Expr1019308
      Expr1033797
      Expr1148350
      Expr2017619
      Expr2035757
    Drives_construct: WBCnstr00006987
      WBCnstr00006999
      WBCnstr00013692
      WBCnstr00032747
    Construct_product (19)
    Antibody: WBAntibody00002363
    Microarray_results (25)
    Expression_cluster (109)
    Interaction (40)
  Map_info: Map: III Position: 21.2132
    Positive: Positive_clone: F11F1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [140424 pad] Modified Map position as the next gene was a reverse physical that could not be fixed by automated methods. (21.2131)
  Method: Gene