WormBase Tree Display for Gene: WBGene00008765
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WBGene00008765 | SMap | S_parent | Sequence | F13G3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ttx | ||||||
Allele (30) | |||||||
Strain | WBStrain00032133 | ||||||
WBStrain00032183 | |||||||
WBStrain00022002 | |||||||
WBStrain00022001 | |||||||
WBStrain00021999 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Contained_in_operon | CEOP1388 | ||||||
Ortholog (42) | |||||||
Paralog | WBGene00012390 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00044063 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | ttx-7 encodes, by alternative splicing, two isoforms of a myo-inositolmonophosphatase (IMPase) required for normal thermotaxis and chemotaxisto sodium, as well as for subcellular localization of SNB-1 and SNG-1 inRIA interneurons; one isoform ('ttx-7a') has much higher transgenicrescuing activity of ttx-7(nj40) than the other ('ttx-7b'), so ttx-7a isconsidered the major isoform in vivo; a rescuing translational fusion ofTTX-7 to EGFP is strongly expressed in coelomocytes and a few head andtail neurons, with weaker expression in motor neurons, intestine, andsomatic gonad; TTX-7::EGFP is cytoplasmic, and can rescue mutantphenotypes when transiently expressed in adults; TTX-7 proteins areorthologous to human IMPA1 (OMIM:602064) and IMPA2 (OMIM:605922),possible mediators of manic depressive psychosis; ttx-7 mutationsdisplay ahtermic and chemotactic phenotypes, partially suppress thethermophilic phenotype of tax-6 mutations, and cause mislocalization ofSNB-1 and SNG-1; while ttx-7 expression is required in RIA to rescuethermotaxis phenotypes, RIA in ttx-7 mutants is morphologically normal;ttx-7 mutant phenotypes can be rescued by exogenous inositol applied toadults; ttx-7 mutations can be phenocopied in wild-type worms by lithiumtreatment of adults, and this phenocopy can be suppressed byoverexpression of a ttx-7 transgene, or by exogenous inositol orsorbitol; ttx-7 mutant development is delayed by exogenous galactose,implying a link between TTX-7/IMPase and galactose metabolism. | Paper_evidence | WBPaper00028886 | |||
WBPaper00029230 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 04 Apr 2007 00:00:00 | ||||||
Automated_description | Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6051) | ||
DOID:0081221 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6050) | ||||
DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6050) | ||||
DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6051) | ||||
Molecular_info | Corresponding_CDS | F13G3.5a | |||||
F13G3.5b | |||||||
Corresponding_CDS_history | F13G3.5:wp68 | ||||||
F13G3.5a:wp176 | |||||||
F13G3.5b:wp176 | |||||||
Corresponding_transcript | F13G3.5a.1 | ||||||
F13G3.5a.2 | |||||||
F13G3.5b.1 | |||||||
Other_sequence (66) | |||||||
Associated_feature | WBsf649306 | ||||||
WBsf663810 | |||||||
WBsf664431 | |||||||
WBsf976775 | |||||||
WBsf976776 | |||||||
WBsf976777 | |||||||
WBsf976778 | |||||||
WBsf219736 | |||||||
Experimental_info | RNAi_result | WBRNAi00003372 | Inferred_automatically | RNAi_primary | |||
WBRNAi00044539 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116918 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00030906 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr3894 | ||||||
Expr4403 | |||||||
Expr1027404 | |||||||
Expr1033823 | |||||||
Expr1148493 | |||||||
Expr2017630 | |||||||
Expr2035770 | |||||||
Drives_construct | WBCnstr00011726 | ||||||
WBCnstr00011971 | |||||||
WBCnstr00032706 | |||||||
Construct_product | WBCnstr00011971 | ||||||
WBCnstr00032706 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (116) | |||||||
Interaction (94) | |||||||
Map_info | Map | I | Position | 1.88331 | Error | 0.002966 | |
Positive | Positive_clone | F13G3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (19) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |