ser-5 encodes a biogenic amine receptor that is most closely related to mammalian serotonin/5-HT-6 receptors; SER-5 functions in the ASH chemosensory neurons to coordinate sensory input and locomotory behavior and in muscles to regulate serotonin's effects on egg laying; heterologously expressed ser-5 has no effect on adenylate cyclase signaling; ser-5 reporter fusions are expressed in vulval and bodywall muscles and head neurons, including ASH and AWB.
Predicted to enable alpha1-adrenergic receptor activity. Involved in several processes, including pharyngeal pumping; positive regulation of egg-laying behavior; and serotonin receptor signaling pathway. Predicted to be located in membrane. Expressed in body wall musculature; egg-laying apparatus; and lateral ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Is an ortholog of human ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.