F21D5.1 encodes a putative phosphoacetylglucosamine mutase orthologousto human PGM3 (OMIM:172100); F21D5.1 is thought to catalyse the thirdstep of the hexosamine pathway to UDP-N-acetylglucosamine orUDP-N-acetylgalactosamine; F21D5.1 transcripts are enriched duringoogenesis; F21D5.1(RNAi) animals have an osmotically-sensitive embryoniclethal phenotype, presumably because of defects in chitin and eggshellsynthesis.
Predicted to enable phosphoacetylglucosamine mutase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Human ortholog(s) of this gene implicated in cervical cancer; immunodeficiency 23; and teratoma. Is an ortholog of human PGM3 (phosphoglucomutase 3).