WormBase Tree Display for Gene: WBGene00009035
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| WBGene00009035 | SMap | S_parent | Sequence | F22B3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gfat-2 | Paper_evidence | WBPaper00045007 | |||||
| Person_evidence | WBPerson759 | ||||||||
| Sequence_name | F22B3.4 | ||||||||
| Molecular_name | F22B3.4 | ||||||||
| F22B3.4.1 | |||||||||
| CE03255 | |||||||||
| F22B3.4.2 | |||||||||
| Other_name | CELE_F22B3.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | gfat-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 28 Apr 2014 09:20:44 | WBPerson2970 | Name_change | CGC_name | gfat-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gfat | ||||||||
| Allele (47) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00065512 | ||||||||
| 00065513 | |||||||||
| 00065514 | |||||||||
| 00065515 | |||||||||
| 00065516 | |||||||||
| 00065517 | |||||||||
| 00065518 | |||||||||
| 00065519 | |||||||||
| 00116820 | |||||||||
| 00116821 | |||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00008546 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gfat-2 encodes a glucosamine--fructose-6-phosphate aminotransferase (EC:2.6.1.16, also known as glutamine-fructose-6-phosphate transaminase), paralogous to GFAT-1; GFAT-2 is predicted to catalyze the first, and rate-limiting, step of the hexosamine pathway in which glucosamine-6-phosphate is synthesized from L-glutamine and fructose-6-phosphate and ultimately converted to UDP-N-acetylglucosamine (UDP-GlcNAc); gfat-2 transcripts are enriched during oogenesis; gfat-2(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis. | Paper_evidence | WBPaper00005599 | |||||
| WBPaper00006390 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00028588 | |||||||||
| WBPaper00045007 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 May 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; and protein N-linked glycosylation. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Is an ortholog of human GFPT1 (glutamine--fructose-6-phosphate transaminase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110660 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4241) | ||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4241) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4241,HGNC:4242) | ||||||
| Molecular_info | Corresponding_CDS | F22B3.4 | |||||||
| Corresponding_transcript | F22B3.4.1 | ||||||||
| F22B3.4.2 | |||||||||
| Other_sequence (64) | |||||||||
| Associated_feature | WBsf646373 | ||||||||
| WBsf997833 | |||||||||
| WBsf1018207 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr1015890 | ||||||||
| Expr1033940 | |||||||||
| Expr1149201 | |||||||||
| Expr2012026 | |||||||||
| Expr2030262 | |||||||||
| Drives_construct | WBCnstr00032507 | ||||||||
| Construct_product | WBCnstr00032507 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (240) | |||||||||
| Interaction (363) | |||||||||
| Map_info | Map | IV | Position | 4.97901 | |||||
| Positive | Positive_clone | F22B3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00045007 | |||||||||
| WBPaper00046159 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059250 | |||||||||
| WBPaper00061547 | |||||||||
| WBPaper00065394 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
