WormBase Tree Display for Gene: WBGene00010283
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| WBGene00010283 | SMap | S_parent | Sequence | F58G11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ccz-1 | Paper_evidence | WBPaper00028972 | |||||
| Person_evidence | WBPerson610 | ||||||||
| Sequence_name | F58G11.6 | ||||||||
| Molecular_name | F58G11.6 | ||||||||
| F58G11.6.1 | |||||||||
| CE11410 | |||||||||
| Other_name | Ce-ccz-1 | Paper_evidence | WBPaper00028972 | ||||||
| CELE_F58G11.6 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | ccz-1 | ||||||||
| DB_info | Database | AceView | gene | 5O161 | |||||
| WormQTL | gene | WBGene00010283 | |||||||
| WormFlux | gene | WBGene00010283 | |||||||
| NDB | locus_tag | CELE_F58G11.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00010283|UniProtKB=Q9XVL8 | |||||||
| family | PTHR13056 | ||||||||
| NCBI | gene | 186547 | |||||||
| RefSeq | protein | NM_073986.4 | |||||||
| TREEFAM | TREEFAM_ID | TF314962 | |||||||
| TrEMBL | UniProtAcc | Q9XVL8 | |||||||
| UniProt_GCRP | UniProtAcc | Q9XVL8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 03 Aug 2009 11:56:38 | WBPerson9133 | Name_change | CGC_name | ccz-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ccz | ||||||||
| Allele (41) | |||||||||
| Strain | WBStrain00022203 | ||||||||
| WBStrain00040549 | |||||||||
| WBStrain00022204 | |||||||||
| WBStrain00022205 | |||||||||
| WBStrain00037030 | |||||||||
| WBStrain00007745 | |||||||||
| WBStrain00007773 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | ccz-1 encodes an ortholog of human C7orf28A and C7orf28B, with more distant similarity to human HPS4 (OMIM:606682) and S. cerevisiae Ccz1p in its N-terminal CHiPS domain;the CHiPS domain of CCZ-1 is predicted to have a longin-like fold; CCZ-1 is required fordigestion of apoptotic corpses, specifically for phagosome maturation via exchange of the RAB-7 GTPase for the RAB-5 GTPase on the maturing phagosome; CCZ-1 is also required for lysosome biogenesis and vesicle transport; CCZ-1 physically interacts with SAND-1, the C. elegans Mon1 ortholog that is also required for processing engulfed apoptotic cells; a CCZ-1::YFP reporter fusion protein is seen in a halo-like pattern around phagosomes containing engulfed apoptotic cells; localization of CCZ-1 to phagosomes requires activity of dyn-1, vps-34, and rab-5, indicating that ccz-1 acts downstream of these genes in regulating apoptotic cell digestion, while overexpression of RAB-7 in ccz-1 mutants partially rescues the abnormal ccz-1 digestion phenotype, suggesting that ccz-1 acts upstream of RAB-7. | Paper_evidence | WBPaper00026670 | |||||
| WBPaper00028972 | |||||||||
| WBPaper00029166 | |||||||||
| WBPaper00029167 | |||||||||
| WBPaper00029168 | |||||||||
| WBPaper00029169 | |||||||||
| WBPaper00036059 | |||||||||
| WBPaper00036342 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 31 Aug 2010 00:00:00 | ||||||||
| Automated_description | Involved in lipid droplet disassembly and phagolysosome assembly involved in apoptotic cell clearance. Located in phagocytic vesicle. Used to study Hermansky-Pudlak syndrome. Is an ortholog of human CCZ1 (CCZ1 homolog, vacuolar protein trafficking and biogenesis associated) and CCZ1B (CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:3753 | Homo sapiens | Paper_evidence | WBPaper00036342 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 02 Jul 2018 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000592 | ||||||||
| WBDOannot00000593 | |||||||||
| WBDOannot00000594 | |||||||||
| Molecular_info | Corresponding_CDS | F58G11.6 | |||||||
| Corresponding_transcript | F58G11.6.1 | ||||||||
| Other_sequence (42) | |||||||||
| Associated_feature | WBsf647475 | ||||||||
| WBsf1001870 | |||||||||
| WBsf1001871 | |||||||||
| WBsf1001872 | |||||||||
| WBsf1020753 | |||||||||
| WBsf1020754 | |||||||||
| WBsf1020755 | |||||||||
| WBsf232812 | |||||||||
| WBsf232813 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00097826 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00097841 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033131 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016010 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049047 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061836 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097819 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1022995 | ||||||||
| Expr1034485 | |||||||||
| Expr1152789 | |||||||||
| Expr2009777 | |||||||||
| Expr2028017 | |||||||||
| Drives_construct | WBCnstr00015978 | ||||||||
| WBCnstr00031529 | |||||||||
| Construct_product | WBCnstr00015977 | ||||||||
| WBCnstr00015978 | |||||||||
| WBCnstr00031529 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (87) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | V | Position | 5.58365 | Error | 0.000508 | |||
| Positive | Positive_clone | F58G11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
