WormBase Tree Display for Gene: WBGene00010354

WBGene00010354 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 2
    Name: CGC_name: cyp-31A2
      Sequence_name: H02I12.8
      Molecular_name: H02I12.8
        H02I12.8.1
        CE37719
      Other_name: CELE_H02I12.8 Accession_evidence: NDB BX284604
      Public_name: cyp-31A2
    DB_info: Database: AceView gene 4M169
        WormQTL gene WBGene00010354
        WormFlux gene WBGene00010354
        OMIM disease 210370
          gene 608614
        NDB locus_tag CELE_H02I12.8
        Panther gene CAEEL|WormBase=WBGene00010354|UniProtKB=G5EGT6
          family PTHR24291
        NCBI gene 178065
        RefSeq protein NM_069751.7
        TrEMBL UniProtAcc G5EGT6
        UniProt_GCRP UniProtAcc G5EGT6
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-31A2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (29)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (49)
    Paralog (11)
    Structured_description: Concise_description: cyp-31A2 encodes a class 4 cytochrome P450 predicted to hydroxylatepolyunsaturated fats (PUFAs); CYP-31A2 is required for sperm to normallymigrate towards a PUFA-based signal exuded by oocytes; cyp-31A2(RNAi)hermaphrodites are infertile, both through aberrant loss of their ownsperm and through failure of males to effectively inseminate them; inmammalian eicosanoid signalling, class 4 cytochrome P450 is required forthe omega hydroxylation of PUFAs, prostaglandins, and leukotrienes. Paper_evidence: WBPaper00028527
          Curator_confirmed: WBPerson567
          Date_last_updated: 12 Mar 2007 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including asymmetric cell division; embryonic morphogenesis; and female gamete generation. Used to study Bietti crystalline corneoretinal dystrophy. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Is an ortholog of human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0050664 Homo sapiens Paper_evidence: WBPaper00033072
          Curator_confirmed: WBPerson324
          Date_last_updated: 11 Mar 2013 00:00:00
    Potential_model: DOID:0050664 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23198)
    Disease_relevance: Mutations in the human CYP4V2, a class 4 cytochrome P450 enzyme are implicated in the retinal disease, Bietti''s Crystalline Dystrophy; elegans cyp-31A2 is most similar to CYP4V2; elegans cyp-31A2 along with cyp-31A1 and cyp-31A3 regulate prostaglandin levels which influence sperm guidance during fertilization. Homo sapiens Paper_evidence: WBPaper00041955
          Accession_evidence: OMIM 210370
              608614
          Curator_confirmed: WBPerson324
          Date_last_updated: 11 Mar 2013 00:00:00
  Models_disease_asserted: WBDOannot00000111
  Molecular_info: Corresponding_CDS: H02I12.8
    Corresponding_CDS_history: H02I12.8:wp92
      H02I12.8:wp134
    Corresponding_transcript: H02I12.8.1
    Other_sequence (18)
    Associated_feature: WBsf660706
      WBsf660707
      WBsf229156
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr1027905
      Expr1034521
      Expr1153011
      Expr2010704
      Expr2028943
    Drives_construct: WBCnstr00031477
    Construct_product: WBCnstr00031477
    Microarray_results (16)
    Expression_cluster (164)
    Interaction (241)
  Map_info: Map: IV Position: 4.97663 Error: 0.00099
    Positive: Positive_clone: H02I12 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00026592
    WBPaper00028352
    WBPaper00028527
    WBPaper00033072
    WBPaper00038491
    WBPaper00042257
    WBPaper00055090
    WBPaper00062625
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene