WormBase Tree Display for Gene: WBGene00010414

WBGene00010414 SMap: S_parent: Sequence: H25K10
  Identity: Version: 2
    Name: CGC_name: hpa-1 Paper_evidence: WBPaper00036312
          Person_evidence: WBPerson145
      Sequence_name: H25K10.5
      Molecular_name: H25K10.5
        H25K10.5.1
        CE19937
      Other_name: CELE_H25K10.5 Accession_evidence: NDB BX284604
      Public_name: hpa-1
    DB_info: Database: AceView gene 4Q988
        WormQTL gene WBGene00010414
        WormFlux gene WBGene00010414
        NDB locus_tag CELE_H25K10.5
        Panther gene CAEEL|WormBase=WBGene00010414|UniProtKB=Q9U3D2
          family PTHR21662
        NCBI gene 186781
        RefSeq protein NM_070523.2
        TREEFAM TREEFAM_ID TF317243
        TrEMBL UniProtAcc Q9U3D2
        UniProt_GCRP UniProtAcc Q9U3D2
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 04 Jun 2010 16:03:52 WBPerson2970 Name_change: CGC_name: hpa-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hpa
    Allele (79)
    Strain: WBStrain00032868
      WBStrain00040803
    RNASeq_FPKM (74)
    GO_annotation: 00100123
    Ortholog (108)
    Paralog (75)
    Structured_description: Concise_description: hpa-1 encodes one of 54 C. elegans insulin receptor-related proteins, predicted secreted proteins that contain regions of similarity to the extracellular ligand-binding domains of the insulin and epidermal growth factor (EGF) receptors; hpa-1 functions in older adult animals to negatively regulate aging-associated changes, such as locomotory capacity, pigment accumulation, and pharyngeal pumping; in regulating these aspects of healthspan, hpa-1 appears to function as a negative regulator of the PLC-3/ITR-1 branch of the LET-23/EGFR-mediated signaling pathway; in larvae and young adults, an hpa-1::GFP fusion is expressed in neurons and the phasmid socket cells; in adults, an hpa-1::GFP is expressed in the posterior intestine, the amphid and phasmid socket cells, and a few neurons. Paper_evidence: WBPaper00036312
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Sep 2010 00:00:00
      Automated_description: Predicted to be located in membrane. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: H25K10.5
    Corresponding_transcript: H25K10.5.1
    Associated_feature: WBsf998829
  Experimental_info: RNAi_result: WBRNAi00016320 Inferred_automatically: RNAi_primary
      WBRNAi00049489 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027314
      Expr1153211
      Expr2012548
    Drives_construct: WBCnstr00031432
    Construct_product: WBCnstr00031432
    Microarray_results (17)
    Expression_cluster (39)
    Interaction (39)
  Map_info: Map: IV Position: 14.6157 Error: 0.000386
    Positive: Positive_clone: H25K10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005154
    WBPaper00032557
    WBPaper00033847
    WBPaper00036312
    WBPaper00036563
    WBPaper00037799
    WBPaper00040976
    WBPaper00046137
    WBPaper00059947
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene