WormBase Tree Display for Gene: WBGene00010492
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| WBGene00010492 | SMap | S_parent | Sequence | K02B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | meg-1 | Person_evidence | WBPerson4009 | |||||
| WBPerson2290 | |||||||||
| Sequence_name | K02B9.1 | ||||||||
| Molecular_name | K02B9.1 | ||||||||
| K02B9.1.1 | |||||||||
| CE16206 | |||||||||
| Other_name | CELE_K02B9.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | meg-1 | ||||||||
| DB_info | Database | AceView | gene | XO546 | |||||
| WormQTL | gene | WBGene00010492 | |||||||
| WormFlux | gene | WBGene00010492 | |||||||
| NDB | locus_tag | CELE_K02B9.1 | |||||||
| NCBI | gene | 181502 | |||||||
| RefSeq | protein | NM_077918.8 | |||||||
| SwissProt | UniProtAcc | Q21126 | |||||||
| UniProt_GCRP | UniProtAcc | Q21126 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 20 Feb 2008 15:36:20 | WBPerson2970 | Name_change | CGC_name | meg-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | meg | ||||||||
| Allele (72) | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00070369 | ||||||||
| 00070370 | |||||||||
| 00070371 | |||||||||
| 00070372 | |||||||||
| 00070373 | |||||||||
| 00070374 | |||||||||
| 00070375 | |||||||||
| 00070376 | |||||||||
| 00070377 | |||||||||
| Contained_in_operon | CEOPX165 | ||||||||
| Ortholog | chrX_pilon.g20494 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Paralog | WBGene00010493 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | meg-1 encodes a novel protein that localizes exclusively to P granules; originally identified by microarray analyses of germline-enriched transcripts, loss of meg-1 activity via mutation and RNAi indicates that MEG-1 is required for germline development and normal levels of fertility; specifically, MEG-1 is required maternally for normal germ cell proliferation and/or survival and for fully normal P granule segregation to the germ cell lineage; in regulating germline development, meg-1 likely functions redundantly with meg-2 and mes-1; meg-1 expression in the proximal germline is positively regulated by MPK-1, the C. elegans MAP kinase ortholog; meg-1 mRNA is expressed in the proximal germline; MEG-1 localizes to P granules from the 4-to-8-cell through 100-cell stage of embryogenesis; MEG-1 localization to P granules partially requires MES-1 and, in turn, MES-1 localization to P granules is partly dependent on MEG-1. | Paper_evidence | WBPaper00028788 | |||||
| WBPaper00031440 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Mar 2008 00:00:00 | ||||||||
| Automated_description | Involved in P granule disassembly and germ cell proliferation. Located in P granule. Expressed in Psub2; Psub3; Psub4; and germ line. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K02B9.1 | |||||||
| Corresponding_transcript | K02B9.1.1 | ||||||||
| Associated_feature | WBsf1007771 | ||||||||
| WBsf238181 | |||||||||
| WBsf238182 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr7958 | ||||||||
| Expr7959 | |||||||||
| Expr13393 | |||||||||
| Expr1011303 | |||||||||
| Expr1034582 | |||||||||
| Expr1153401 | |||||||||
| Expr2013508 | |||||||||
| Expr2031742 | |||||||||
| Drives_construct | WBCnstr00031380 | ||||||||
| Construct_product | WBCnstr00005570 | ||||||||
| WBCnstr00031380 | |||||||||
| Regulate_expr_cluster | WBPaper00064559:meg-1(vr10)meg-2(RNAi)_downregulated | ||||||||
| WBPaper00064559:meg-1(vr10)meg-2(RNAi)_upregulated | |||||||||
| Antibody | WBAntibody00001366 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (245) | |||||||||
| Interaction (154) | |||||||||
| Map_info | Map | X | Position | 15.4373 | Error | 0.044397 | |||
| Positive | Positive_clone | K02B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00010795 | ||||||||
| WBPaper00031440 | |||||||||
| WBPaper00036884 | |||||||||
| WBPaper00037500 | |||||||||
| WBPaper00038112 | |||||||||
| WBPaper00046196 | |||||||||
| WBPaper00051310 | |||||||||
| WBPaper00052021 | |||||||||
| WBPaper00055334 | |||||||||
| WBPaper00064559 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
