WormBase Tree Display for Gene: WBGene00010808
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| WBGene00010808 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sepa-1 | Paper_evidence | WBPaper00032509 | |||||
| Person_evidence | WBPerson716 | ||||||||
| Sequence_name | M01E5.6 | ||||||||
| Molecular_name | M01E5.6 | ||||||||
| M01E5.6.1 | |||||||||
| CE12286 | |||||||||
| Other_name | CELE_M01E5.6 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | sepa-1 | ||||||||
| DB_info | Database | AceView | gene | 1N890 | |||||
| WormQTL | gene | WBGene00010808 | |||||||
| WormFlux | gene | WBGene00010808 | |||||||
| NDB | locus_tag | CELE_M01E5.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00010808|UniProtKB=G5EC37 | |||||||
| family | PTHR21504 | ||||||||
| NCBI | gene | 173196 | |||||||
| RefSeq | protein | NM_060938.4 | |||||||
| SwissProt | UniProtAcc | G5EC37 | |||||||
| TREEFAM | TREEFAM_ID | TF322610 | |||||||
| UniProt_GCRP | UniProtAcc | G5EC37 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Feb 2009 12:24:54 | WBPerson2970 | Name_change | CGC_name | sepa-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sepa | ||||||||
| Allele (52) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (31) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | sepa-1 encodes a self associating adaptor protein of 702 amino acids rich in helical structures at its N-terminus and a protein interaction KIX domain at the C-terminus; SEPA-1 is required for degradation of germline P granule components PGL-1 and PGL-3 in somatic cells by the autophagic machinery; sepa-1 forms protein aggregates and is preferentially removed by autophagy during embryogenesis; SEPA-1 functions as a bridging molecule in mediating the specific recognition and degradation of P granule components by autophagy; SEPA-1 directly interacts with PGL-3 and LGG-1; sepa-1 is involved in the clearance of maternally derived P granule components in somatic cells; SEPA-1 family members display a dynamic expression pattern during embryogenesis; SEPA-1 aggregates are found in 16-cell stage embryos, and the number of SEPA-1 aggregates increases as the embryo develops to the 100-cell stage; as development proceeds, SEPA-1 aggregates disappears. | Paper_evidence | WBPaper00032509 | |||||
| WBPaper00033110 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 13 Jul 2011 00:00:00 | ||||||||
| Automated_description | Enables protein self-association and protein-macromolecule adaptor activity. Involved in autophagy. Located in cytoplasm. Expressed in head; intestine; and tail. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | M01E5.6 | |||||||
| Corresponding_transcript | M01E5.6.1 | ||||||||
| Associated_feature | WBsf665054 | ||||||||
| WBsf665055 | |||||||||
| WBsf665056 | |||||||||
| WBsf665057 | |||||||||
| WBsf220491 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00034360 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050764 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00080469 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017101 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8544 | ||||||||
| Expr8545 | |||||||||
| Expr14425 | |||||||||
| Expr14533 | |||||||||
| Expr1013683 | |||||||||
| Expr1034735 | |||||||||
| Expr1154461 | |||||||||
| Expr2015745 | |||||||||
| Expr2033978 | |||||||||
| Drives_construct | WBCnstr00005616 | ||||||||
| WBCnstr00006904 | |||||||||
| WBCnstr00013358 | |||||||||
| WBCnstr00018446 | |||||||||
| WBCnstr00018461 | |||||||||
| Construct_product | WBCnstr00006904 | ||||||||
| WBCnstr00013358 | |||||||||
| Antibody | WBAntibody00001612 | ||||||||
| WBAntibody00002777 | |||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (195) | |||||||||
| Interaction (142) | |||||||||
| Map_info | Map | I | Position | 17.5233 | Error | 0.036554 | |||
| Positive | Positive_clone | M01E5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
