WormBase Tree Display for Gene: WBGene00010941
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| WBGene00010941 | SMap | S_parent | Sequence | M176 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gss-1 | Person_evidence | WBPerson3046 | |||||
| Sequence_name | M176.2 | ||||||||
| Molecular_name | M176.2 | ||||||||
| M176.2.1 | |||||||||
| CE18087 | |||||||||
| Other_name | CELE_M176.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | gss-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 18 Mar 2011 16:31:15 | WBPerson2970 | Name_change | CGC_name | gss-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gss | ||||||||
| Allele (30) | |||||||||
| Strain | WBStrain00001901 | ||||||||
| WBStrain00001902 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | gss-1 encodes the C. elegans ortholog of glutathione synthetase (GSS; OMIM:601002), which when mutated leads to 5-oxoprolinuria, or to GSS deficiency restricted to erythrocytes and associated only with hemolytic anemia; GSS-1 is predicted to catalyze the second step of glutathione (GSH) biosynthesis in which the dipeptide c-Glu-Cys is conjugated with glycine. | Paper_evidence | WBPaper00004637 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Dec 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be located in cytosol. Expressed in head. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Is an ortholog of human GSS (glutathione synthetase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4624) | ||||
| DOID:0080699 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4624) | ||||||
| DOID:0081034 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4624) | ||||||
| DOID:0112252 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4624) | ||||||
| Molecular_info | Corresponding_CDS | M176.2 | |||||||
| Corresponding_transcript | M176.2.1 | ||||||||
| Other_sequence (25) | |||||||||
| Associated_feature | WBsf019117 | ||||||||
| WBsf019118 | |||||||||
| WBsf019119 | |||||||||
| WBsf019120 | |||||||||
| WBsf655382 | |||||||||
| WBsf223647 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00025998 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00115452 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009015 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033513 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115518 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050997 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1317 | ||||||||
| Expr6428 | |||||||||
| Expr6429 | |||||||||
| Expr6430 | |||||||||
| Expr1024814 | |||||||||
| Expr1034802 | |||||||||
| Expr1154705 | |||||||||
| Expr2012292 | |||||||||
| Expr2030528 | |||||||||
| Drives_construct | WBCnstr00002692 | ||||||||
| WBCnstr00002693 | |||||||||
| WBCnstr00004395 | |||||||||
| WBCnstr00031040 | |||||||||
| Construct_product | WBCnstr00031040 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (71) | |||||||||
| Map_info | Map | II | Position | 1.39871 | Error | 0.004281 | |||
| Positive | Positive_clone | M176 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006024 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00045711 | |||||||||
| WBPaper00048470 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059495 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
