WormBase Tree Display for Gene: WBGene00011009

WBGene00011009 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: cyp-14A4
      Sequence_name: R04D3.1
      Molecular_name: R04D3.1
        R04D3.1.1
        CE06222
      Other_name: CELE_R04D3.1 Accession_evidence: NDB BX284606
      Public_name: cyp-14A4
    DB_info: Database: AceView gene XN898
        WormQTL gene WBGene00011009
        WormFlux gene WBGene00011009
        NDB locus_tag CELE_R04D3.1
        Panther gene CAEEL|WormBase=WBGene00011009|UniProtKB=G5ED86
          family PTHR24284
        NCBI gene 187573
        RefSeq protein NM_077806.5
        TrEMBL UniProtAcc G5ED86
        UniProt_GCRP UniProtAcc G5ED86
        OMIM gene 610670
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-14A4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (43)
    RNASeq_FPKM (74)
    GO_annotation: 00013539
      00013540
      00013541
      00118321
      00118322
      00118323
      00118324
    Ortholog (57)
    Paralog (42)
    Structured_description: Concise_description: cyp-14A4 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates. Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2008 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; hematologic cancer (multiple); and hereditary spastic paraplegia 56. Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: R04D3.1
    Corresponding_transcript: R04D3.1.1
    Other_sequence (17)
    Associated_feature: WBsf982264
  Experimental_info: RNAi_result: WBRNAi00092635 Inferred_automatically: RNAi_primary
      WBRNAi00034580 Inferred_automatically: RNAi_primary
      WBRNAi00087701 Inferred_automatically: RNAi_primary
      WBRNAi00070067 Inferred_automatically: RNAi_primary
      WBRNAi00116300 Inferred_automatically: RNAi_primary
      WBRNAi00051233 Inferred_automatically: RNAi_primary
      WBRNAi00017399 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr14275
      Expr1013332
      Expr1154936
    Drives_construct: WBCnstr00030996
      WBCnstr00040613
    Construct_product: WBCnstr00030996
    Microarray_results (16)
    Expression_cluster (155)
    Interaction (15)
  Map_info: Map: X Position: 11.1493 Error: 0.008401
    Positive: Positive_clone: R04D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00062420
    WBPaper00062515
    WBPaper00064708
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene