WormBase Tree Display for Gene: WBGene00011201
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| WBGene00011201 | SMap | S_parent | Sequence | R10E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | nth-1 | Paper_evidence | WBPaper00027694 | |||||
| Person_evidence | WBPerson184 | ||||||||
| Sequence_name | R10E4.5 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | nthl-1 | Person_evidence | WBPerson2696 | ||||||
| CAA90766 | Paper_evidence | WBPaper00036139 | |||||||
| CELE_R10E4.5 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | nth-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 19 May 2006 13:14:18 | WBPerson2970 | Name_change | CGC_name | nthl-1 | ||||
| 3 | 28 Jul 2006 10:20:51 | WBPerson2970 | Name_change | CGC_name | nth-1 | ||||
| Other_name | nthl-1 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nth | ||||||||
| Allele (40) | |||||||||
| Strain | WBStrain00031590 | ||||||||
| Component_of_genotype | WBGenotype00000107 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (39) | |||||||||
| Contained_in_operon | CEOP3898 | ||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | nth-1 encodes a DNA N-glycosylase of the endonuclease III family orthologous to human NTH1; by homology, NTH-1 is predicted to function in vivo as part of the base excision repair pathway by catalyzing removal of oxidatively damaged pyrimidine bases, and nth-1-deficient animals display an increase in total mutation rate when compared to wild-type animals over multiple generations; in vitro, NTH-1 exhibits DNA N-glycosylase activity, excising Tg, 5-formyluracil (5-foU), and 5-hydroxymethyluracil (5-hmU) from DNA, and weakly excising 8-oxoG paired with G; when expressed in E. coli SY5 nth nei double mutants, nth-1 can rescue the hydrogen peroxide sensitivity presumably due to its ability to repair oxidized pyrimidine bases. | Paper_evidence | WBPaper00027694 | |||||
| WBPaper00033412 | |||||||||
| WBPaper00036139 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Apr 2010 00:00:00 | ||||||||
| Automated_description | Enables 5-formyluracil DNA N-glycosylase activity and 5-hydroxymethyluracil DNA N-glycosylase activity. Involved in cellular response to hydrogen peroxide and depyrimidination. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Is an ortholog of human NTHL1 (nth like DNA glycosylase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080411 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8028) | ||||
| Molecular_info | Corresponding_CDS | R10E4.5a | |||||||
| R10E4.5b | |||||||||
| R10E4.5c | |||||||||
| R10E4.5d | |||||||||
| Corresponding_CDS_history | R10E4.5:wp206 | ||||||||
| R10E4.5:wp212 | |||||||||
| Corresponding_transcript | R10E4.5a.1 | ||||||||
| R10E4.5b.1 | |||||||||
| R10E4.5c.1 | |||||||||
| R10E4.5d.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf226513 | ||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr1011202 | ||||||||
| Expr1034918 | |||||||||
| Expr1155382 | |||||||||
| Expr2014510 | |||||||||
| Expr2032749 | |||||||||
| Drives_construct | WBCnstr00030850 | ||||||||
| Construct_product | WBCnstr00030850 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (59) | |||||||||
| Map_info | Map | III | Position | -3.21568 | Error | 0.007844 | |||
| Positive | Positive_clone | R10E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
