WormBase Tree Display for Gene: WBGene00011216
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| WBGene00011216 | SMap | S_parent | Sequence | R10E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | usp-46 | Person_evidence | WBPerson555 | |||||
| WBPerson3536 | |||||||||
| Sequence_name | R10E11.3 | ||||||||
| Molecular_name | R10E11.3a | ||||||||
| R10E11.3a.1 | |||||||||
| CE41150 | |||||||||
| R10E11.3b | |||||||||
| CE41151 | |||||||||
| R10E11.3b.1 | |||||||||
| Other_name | toe-3 | ||||||||
| CELE_R10E11.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | usp-46 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Mar 2009 11:15:07 | WBPerson9133 | Name_change | CGC_name | toe-3 | ||||
| 3 | 31 Mar 2009 10:08:04 | WBPerson9133 | Name_change | CGC_name | usp-46 | ||||
| Other_name | toe-3 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | usp | ||||||||
| Allele (29) | |||||||||
| Strain | WBStrain00032438 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00017280 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | usp-46 encodes a cysteine protease that is a member of the deubiquitinating enzyme (ubiquitin-specific protease) family; USP-46 functions in the ventral nerve cord to positively regulate levels of the GLR-1 glutamate receptor by regulating GLR-1 degradation in the multi-vesicular body (MVB)/lysosome pathway; accordingly, usp-46 mutant animals display defects in glr-1-mediated behaviors and USP-46 and GLR-1 physically interact; a usp-46 promoter fusion is widely expressed and seen in the ventral nerve cord, pharynx, body wall muscle, vulva muscle, and intestine; USP-46 localizes to the cell body and the cytoplasm and partially overlaps with endosomes. | Paper_evidence | WBPaper00038120 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Mar 2011 00:00:00 | ||||||||
| Automated_description | Enables cysteine-type deubiquitinase activity and ionotropic glutamate receptor binding activity. Involved in anterior/posterior axis specification, embryo; positive regulation of gene expression; and positive regulation of locomotion involved in locomotory behavior. Located in endosome and neuronal cell body. Expressed in body wall musculature; intestine; nervous system; pharynx; and vulval muscle. Is an ortholog of human USP46 (ubiquitin specific peptidase 46). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R10E11.3a | |||||||
| R10E11.3b | |||||||||
| Corresponding_CDS_history | R10E11.3a:wp176 | ||||||||
| R10E11.3b:wp176 | |||||||||
| Corresponding_transcript | R10E11.3a.1 | ||||||||
| R10E11.3b.1 | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf645515 | ||||||||
| WBsf993800 | |||||||||
| WBsf1015671 | |||||||||
| WBsf225617 | |||||||||
| WBsf225618 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr3642 | ||||||||
| Expr11527 | |||||||||
| Expr11528 | |||||||||
| Expr14998 | |||||||||
| Expr1018794 | |||||||||
| Expr1034923 | |||||||||
| Expr1155368 | |||||||||
| Expr2017938 | |||||||||
| Expr2036074 | |||||||||
| Drives_construct | WBCnstr00007986 | ||||||||
| WBCnstr00007987 | |||||||||
| WBCnstr00030839 | |||||||||
| Construct_product | WBCnstr00007984 | ||||||||
| WBCnstr00007985 | |||||||||
| WBCnstr00007994 | |||||||||
| WBCnstr00011567 | |||||||||
| WBCnstr00030839 | |||||||||
| WBCnstr00041659 | |||||||||
| WBCnstr00041792 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | III | Position | 1.01722 | Error | 0.004814 | |||
| Positive | Positive_clone | R10E11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
