WormBase Tree Display for Gene: WBGene00011261
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WBGene00011261 | SMap | S_parent | Sequence | CHROMOSOME_V | |||
---|---|---|---|---|---|---|---|
Identity | Version | 4 | |||||
Name | CGC_name | nphp-4 | Person_evidence | WBPerson44 | |||
Sequence_name | R13H4.1 | ||||||
Molecular_name | R13H4.1 | ||||||
R13H4.1.1 | |||||||
CE38409 | |||||||
Other_name | nph-4 | ||||||
CELE_R13H4.1 | Accession_evidence | NDB | BX284605 | ||||
Public_name | nphp-4 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (4) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nphp | ||||||
Allele (151) | |||||||
Strain | WBStrain00031067 | ||||||
WBStrain00031068 | |||||||
Component_of_genotype | WBGenotype00000132 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (38) | |||||||
Ortholog (65) | |||||||
Structured_description | Concise_description | nphp-4 encodes an ortholog of human NPHP4 (OMIM:607215, mutated injuvenile nephronophthisis and Senior-Loken syndrome-4) that is requiredfor normal chemotaxis, lifespan, and male mating behavior; NPHP-4 isexpressed in diverse neurons (amphid and phasmid sensory, URX, labial,male lumbar and cloacal ganglia, and male-specific CEM, HOB and RnB);within neurons, NPHP-4 is a ciliary protein, localized to the transistionzone at cilial bases rather than ciliary axonemes, and absent fromsomata, axons, or dendrites; NPHP-4 colocalizes with NPHP-1 and PKD-2 inmale-specific sensory cilia, and is required for the normal ciliarylocalization of NPHP-1; NPHP-4 expression requires DAF-19, and mutating anX-box in nphp-4's promoter abolishes nphp-4 expression; NPHP-4 is requiredfor NPHP-1's localization to transistion zones; morphologically, nphp-4mutant cilia are normal, indicating a function for NPHP-4 in signaltransduction. | Paper_evidence | WBPaper00024994 | |||
WBPaper00025076 | |||||||
WBPaper00025119 | |||||||
WBPaper00027772 | |||||||
WBPaper00028471 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 25 Jan 2011 00:00:00 | ||||||
Automated_description | Involved in several processes, including determination of adult lifespan; male mating behavior; and plasma membrane bounded cell projection organization. Located in ciliary basal body; ciliary transition zone; and non-motile cilium. Expressed in cloacal ganglion; neurons; and tail ganglion. Used to study Meckel syndrome and nephronophthisis. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 4; Senior-Loken syndrome; and nephronophthisis 4. Is an ortholog of human NPHP4 (nephrocystin 4). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:12712 | Homo sapiens | Paper_evidence | WBPaper00031566 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 May 2018 00:00:00 | ||||||
DOID:0050778 | |||||||
DOID:0060340 | |||||||
Potential_model | DOID:1682 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | |||
DOID:0110999 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||
DOID:0111115 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||
DOID:0050576 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||
DOID:12712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||
Models_disease_asserted | WBDOannot00000032 | ||||||
WBDOannot00000123 | |||||||
WBDOannot00000124 | |||||||
WBDOannot00000136 | |||||||
WBDOannot00000137 | |||||||
WBDOannot00000138 | |||||||
WBDOannot00000305 | |||||||
WBDOannot00000306 | |||||||
WBDOannot00000518 | |||||||
WBDOannot00000615 | |||||||
Molecular_info | Corresponding_CDS | R13H4.1 | |||||
Corresponding_CDS_history | R13H4.1:wp109 | ||||||
R13H4.1:wp141 | |||||||
Corresponding_transcript | R13H4.1.1 | ||||||
Other_sequence | EY472394.1 | ||||||
EY462234.1 | |||||||
ACC13914_1 | |||||||
EY461993.1 | |||||||
Associated_feature | WBsf653157 | ||||||
WBsf669422 | |||||||
WBsf669423 | |||||||
WBsf669424 | |||||||
WBsf1001453 | |||||||
WBsf1001454 | |||||||
WBsf1001455 | |||||||
WBsf234588 | |||||||
Experimental_info | RNAi_result | WBRNAi00017847 | Inferred_automatically | RNAi_primary | |||
WBRNAi00060981 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00034929 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00060980 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00051936 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00051935 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (14) | |||||||
Drives_construct (15) | |||||||
Construct_product (12) | |||||||
Microarray_results (22) | |||||||
Expression_cluster (168) | |||||||
Interaction (13) | |||||||
Map_info | Map | V | Position | 3.42069 | Error | 0.011453 | |
Positive | Positive_clone | R13H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4408 | |||||
4808 | |||||||
4844 | |||||||
Pseudo_map_position | |||||||
Reference (44) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |