WormBase Tree Display for Gene: WBGene00011510
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| WBGene00011510 | SMap | S_parent | Sequence | T05H10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pdha-1 | Person_evidence | WBPerson1983 | |||||
| WBPerson261 | |||||||||
| Sequence_name | T05H10.6 | ||||||||
| Molecular_name | T05H10.6a | ||||||||
| T05H10.6a.1 | |||||||||
| CE01643 | |||||||||
| T05H10.6b | |||||||||
| CE32929 | |||||||||
| T05H10.6a.2 | |||||||||
| T05H10.6a.3 | |||||||||
| T05H10.6b.1 | |||||||||
| Other_name | CELE_T05H10.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | pdha-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 08 Dec 2011 12:14:43 | WBPerson2970 | Name_change | CGC_name | pdha-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pdha | ||||||||
| Allele (19) | |||||||||
| Strain | WBStrain00051190 | ||||||||
| WBStrain00051904 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP2336 | ||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00012713 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1; OMIM:312170), which when mutated leads to Leigh syndrome (OMIM:256000). | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00004637 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure. Is an ortholog of human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8807) | ||||
| DOID:3649 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8806) | ||||||
| Molecular_info | Corresponding_CDS | T05H10.6a | |||||||
| T05H10.6b | |||||||||
| Corresponding_transcript | T05H10.6a.1 | ||||||||
| T05H10.6a.2 | |||||||||
| T05H10.6a.3 | |||||||||
| T05H10.6b.1 | |||||||||
| Other_sequence (156) | |||||||||
| Associated_feature | WBsf657930 | ||||||||
| WBsf221680 | |||||||||
| WBsf221681 | |||||||||
| WBsf221682 | |||||||||
| Experimental_info | RNAi_result (24) | ||||||||
| Expr_pattern | Expr1025242 | ||||||||
| Expr1035071 | |||||||||
| Expr1156193 | |||||||||
| Expr2014802 | |||||||||
| Expr2033036 | |||||||||
| Drives_construct | WBCnstr00030600 | ||||||||
| Construct_product | WBCnstr00030600 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (108) | |||||||||
| Interaction (78) | |||||||||
| Map_info | Map | II | Position | 0.661005 | |||||
| Positive | Positive_clone | T05H10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027145 | ||||||||
| WBPaper00031648 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00044730 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056909 | |||||||||
| WBPaper00059520 | |||||||||
| WBPaper00060084 | |||||||||
| WBPaper00065824 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
