WormBase Tree Display for Gene: WBGene00011605
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| WBGene00011605 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | sftb-1 | Person_evidence | WBPerson2214 | |||||
| Sequence_name | T08A11.2 | ||||||||
| Molecular_name | T08A11.2 | ||||||||
| T08A11.2.1 | |||||||||
| CE03641 | |||||||||
| Other_name | phi-11 | Person_evidence | WBPerson2582 | ||||||
| CELE_T08A11.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | sftb-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 17 Mar 2005 13:54:35 | WBPerson2970 | Name_change | Other_name | phi-11 | ||||
| 3 | 07 Jun 2016 16:25:01 | WBPerson2970 | Name_change | CGC_name | sftb-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sftb | ||||||||
| Allele (75) | |||||||||
| Strain | WBStrain00047225 | ||||||||
| WBStrain00047226 | |||||||||
| WBStrain00049463 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOP3164 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | T08A11.2 encodes the C. elegans ortholog of splicing factor 3b subunit 1, also known as SAP155; by homology, the product of T08A11.2 is predicted to be a component of the U2 snRNP that is required for pre-mRNA splicing; large-scale RNAi assays indicate that T08A11.2 activity is essential for a number of processes including embryonic development, normal adult lifespan, vulval morphogenesis, locomotion, and transgene expression and localization. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00006395 | |||||||||
| WBPaper00006510 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00028383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Feb 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA binding activity. Involved in negative regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of U2 snRNP; U2-type prespliceosome; and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Is an ortholog of human SF3B1 (splicing factor 3b subunit 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10768) | ||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10768) | ||||||
| Molecular_info | Corresponding_CDS | T08A11.2 | |||||||
| Corresponding_transcript | T08A11.2.1 | ||||||||
| Other_sequence (77) | |||||||||
| Associated_feature | WBsf666764 | ||||||||
| WBsf226500 | |||||||||
| WBsf226501 | |||||||||
| WBsf226502 | |||||||||
| Experimental_info | RNAi_result (39) | ||||||||
| Expr_pattern | Expr1017092 | ||||||||
| Expr1035116 | |||||||||
| Expr1156419 | |||||||||
| Expr2015790 | |||||||||
| Expr2034023 | |||||||||
| Regulate_expr_cluster | WBPaper00058725:sftb-1(cer6)_downregulated | ||||||||
| WBPaper00058725:sftb-1(cer6)_upregulated | |||||||||
| WBPaper00058725:sftb-1(cer39)_downregulated | |||||||||
| WBPaper00058725:sftb-1(cer39)_upregulated | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (288) | |||||||||
| WBProcess | WBbiopr:00000120 | ||||||||
| Map_info | Positive | Positive_clone | T08A11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | III | -3.32042 | |||||||
| Reference | WBPaper00027739 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00058092 | |||||||||
| WBPaper00058725 | |||||||||
| Method | Gene |
