WormBase Tree Display for Gene: WBGene00011955
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| WBGene00011955 | SMap | S_parent | Sequence | T23F11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cdka-1 | Person_evidence | WBPerson87 | |||||
| Sequence_name | T23F11.3 | ||||||||
| Molecular_name | T23F11.3a | ||||||||
| T23F11.3a.1 | |||||||||
| CE33707 | |||||||||
| T23F11.3b | |||||||||
| CE01096 | |||||||||
| T23F11.3b.1 | |||||||||
| Other_name | CELE_T23F11.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cdka-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00011955 | |||||
| WormFlux | gene | WBGene00011955 | |||||||
| OMIM | disease | 607432 | |||||||
| NDB | locus_tag | CELE_T23F11.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011955|UniProtKB=Q22695 | |||||||
| family | PTHR23401 | ||||||||
| NCBI | gene | 188812 | |||||||
| RefSeq | protein | NM_001083181.6 | |||||||
| NM_001083180.4 | |||||||||
| SwissProt | UniProtAcc | Q22695 | |||||||
| UniProt_GCRP | UniProtAcc | Q22695 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 09 Sep 2005 10:27:51 | WBPerson2970 | Name_change | CGC_name | cdka-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdka | ||||||||
| Allele (50) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | cdka-1 encodes the C. elegans ortholog of the cyclin-dependent kinase 5 (CDK5) activator p35/Nck5a; cdka-1 activity is required to prevent convulsions induced by exposure to the GABA antagonist pentylenetetrazole (PTZ); in addition, cdka-1 is required for normal distribution of GABA-containing synaptic vesicles in the ventral nerve cord and for regulation of localization of LIN-10 in response to hypoxia; a CDKA-1::GFP translational fusion protein is expressed in all neuronal classes in the ventral nerve cord. | Paper_evidence | WBPaper00028525 | |||||
| WBPaper00040649 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Feb 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Involved in GABAergic synaptic transmission; regulation of cellular localization; and synaptic vesicle transport. Predicted to be located in cytoplasm and growth cone. Predicted to be part of protein kinase 5 complex. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1) and CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Aug 2021 00:00:00 | ||||||||
| DOID:0050453 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||||
| Accession_evidence | OMIM | 607432 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Apr 2013 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1775) | |||||
| Disease_relevance | In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; studies in the worm show that cdka-1 (orthologous to human CDK5R1 and CDK5R2), is a LIS1 pathway component and worms depleted for LIS1 pathway components via RNA interference: NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1, also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background, when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. | Homo sapiens | Curator_confirmed | WBPerson324 | |||||
| Models_disease_in_annotation | WBDOannot00000152 | ||||||||
| WBDOannot00001014 | |||||||||
| Molecular_info | Corresponding_CDS | T23F11.3a | |||||||
| T23F11.3b | |||||||||
| Corresponding_CDS_history | T23F11.3:wp98 | ||||||||
| Corresponding_transcript | T23F11.3a.1 | ||||||||
| T23F11.3b.1 | |||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf224775 | ||||||||
| WBsf224776 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00035869 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005539 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019085 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053941 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4250 | ||||||||
| Expr9054 | |||||||||
| Expr1013122 | |||||||||
| Expr1035278 | |||||||||
| Expr1157487 | |||||||||
| Expr2009816 | |||||||||
| Expr2028057 | |||||||||
| Drives_construct | WBCnstr00011859 | ||||||||
| WBCnstr00030254 | |||||||||
| Construct_product | WBCnstr00007065 | ||||||||
| WBCnstr00007066 | |||||||||
| WBCnstr00007074 | |||||||||
| WBCnstr00007498 | |||||||||
| WBCnstr00011859 | |||||||||
| WBCnstr00014817 | |||||||||
| WBCnstr00030254 | |||||||||
| WBCnstr00038220 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (198) | |||||||||
| Interaction | WBInteraction000034718 | ||||||||
| WBInteraction000034719 | |||||||||
| WBInteraction000052649 | |||||||||
| WBInteraction000401285 | |||||||||
| WBInteraction000518631 | |||||||||
| WBInteraction000548697 | |||||||||
| Map_info | Positive | Positive_clone | T23F11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Mapping_data | Multi_point | 5478 | |||||||
| Interpolated_map_position | III | -2.95019 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00028525 | ||||||||
| WBPaper00030393 | |||||||||
| WBPaper00030893 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040649 | |||||||||
| WBPaper00053726 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00063952 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
