WormBase Tree Display for Gene: WBGene00012857
expand all nodes | collapse all nodes | view schema
WBGene00012857 | SMap | S_parent | Sequence | CHROMOSOME_V | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | pbo | |||||
Allele (126) | ||||||
Legacy_information | [C.elegansII] sa242 : pBoc step of defecation motor program completely absent, other aspects of motor program and timing normal; apparently normal feeding. NA1. [JT] | |||||
Strain | WBStrain00006657 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (18) | ||||||
Ortholog (26) | ||||||
Paralog (100) | ||||||
Structured_description | Concise_description | pbo-5 encodes a proton-gated ion channel required for normal posterior body muscle contractions during defecation; PBO-5 has no obvious non-nematode orthologs, but is paralogous to PBO-6/LGC-3; PBO-5 is expressed in the most posterior bodywall muscles, and in the head neurons RIFL, RIFR, and RIS; heterologous PBO-5/PBO-6 produces strong currents in Xenopus oocytes when stimulated by pH 6.0; pbo-5 mutants are completely deficient in posterior contractions, but move normally, indicating that their defect is in defecation rather than in a more general one in posterior muscle function; pbo-5 mutants have normal PBO-4-mediated acidification pulses at the basolateral face of the posterior intestine, yet fail to contract. | Paper_evidence | WBPaper00001256 | ||
WBPaper00031426 | ||||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 05 Feb 2008 00:00:00 | |||||
Automated_description | Enables extracellular ligand-gated monoatomic ion channel activity. Involved in defecation; lipid transport involved in lipid storage; and positive regulation of multicellular organismal process. Predicted to be located in neuron projection and synapse. Expressed in RIFL; RIFR; RIS; and body wall musculature. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | Y44A6E.1a | ||||
Y44A6E.1b | ||||||
Corresponding_CDS_history | Y44A6E.1:wp87 | |||||
Corresponding_transcript | Y44A6E.1a.1 | |||||
Y44A6E.1b.1 | ||||||
Other_sequence | Tcol_isotig20449 | |||||
Oden_isotig15669 | ||||||
Associated_feature | WBsf647774 | |||||
WBsf662288 | ||||||
WBsf662289 | ||||||
WBsf1003664 | ||||||
WBsf1003665 | ||||||
WBsf1003666 | ||||||
WBsf1022027 | ||||||
WBsf1022028 | ||||||
WBsf1022029 | ||||||
Experimental_info | RNAi_result | WBRNAi00066374 | Inferred_automatically | RNAi_primary | ||
WBRNAi00056554 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr9628 | |||||
Expr1012602 | ||||||
Expr1160028 | ||||||
Expr2014762 | ||||||
Expr2032996 | ||||||
Drives_construct | WBCnstr00014189 | |||||
Construct_product | WBCnstr00042604 | |||||
Microarray_results (24) | ||||||
Expression_cluster (104) | ||||||
Interaction | WBInteraction000554935 | |||||
WBInteraction000556792 | ||||||
Map_info | Map | V | Position | 25.8116 | ||
Positive | Positive_clone | Y44A6E | Inferred_automatically | From sequence, transcript, pseudogene data | ||
Pseudo_map_position | ||||||
Reference (12) | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |