WormBase Tree Display for Gene: WBGene00013096
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| WBGene00013096 | SMap | S_parent | Sequence | Y51H1A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | mcd-1 | Paper_evidence | WBPaper00029005 | |||||
| Person_evidence | WBPerson268 | ||||||||
| Sequence_name | Y51H1A.6 | ||||||||
| Molecular_name | Y51H1A.6a | ||||||||
| Y51H1A.6a.1 | |||||||||
| CE43312 | |||||||||
| Y51H1A.6b | |||||||||
| CE43386 | |||||||||
| Y51H1A.6b.1 | |||||||||
| Other_name | CELE_Y51H1A.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | mcd-1 | ||||||||
| DB_info | Database | AceView | gene | 2O187 | |||||
| WormQTL | gene | WBGene00013096 | |||||||
| WormFlux | gene | WBGene00013096 | |||||||
| NDB | locus_tag | CELE_Y51H1A.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00013096|UniProtKB=B7FAS0 | |||||||
| family | PTHR33936 | ||||||||
| NCBI | gene | 175040 | |||||||
| RefSeq | protein | NM_001267484.3 | |||||||
| NM_001267483.3 | |||||||||
| SwissProt | UniProtAcc | B7FAS0 | |||||||
| TREEFAM | TREEFAM_ID | TF350417 | |||||||
| UniProt_GCRP | UniProtAcc | B7FAS0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Feb 2007 17:11:41 | WBPerson2970 | Name_change | CGC_name | mcd-1 | ||||
| 3 | 27 Nov 2008 11:58:21 | WBPerson1983 | Event | Acquires_merge | WBGene00013097 | ||||
| Acquires_merge | WBGene00013097 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mcd | ||||||||
| Allele (379) | |||||||||
| Strain | WBStrain00027387 | ||||||||
| WBStrain00047498 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (21) | |||||||||
| Paralog | WBGene00012243 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00013006 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00020630 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00019304 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00021704 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00020942 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00018671 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00019159 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00020763 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00019824 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | mcd-1 encodes a highly acidic C2H2-type zinc-finger protein that, inconjunction with LIN-35/Rb, DPL-1/DP, EFL-1/E2F, LIN-37/Mip40, andLIN-52, promotes the developmentally programmed progression of cellsthrough full apoptosis; MCD-1 can promote ectopic apoptosis in cellsnormally fated to live, and is thus active in such cells; MCD-1 is notrequired for CED-3-independent cell death, does not regulate CED-9, andprobably does not transcriptionally regulate egl-1; MCD-1 and itspartners do not act together with CED-1 or CED-8, and their function incell death is distinct from the LET-60/RAS or SynMuv pathways; however,MCD-1 is redundantly required with some class B/C synMuv proteins forviability (LIN-9, LIN-35/Rb, or LIN-37/Mip40) and normally rapid growth(DPL-1/DP, LIN-13, LIN-53, LIN-54, or MYS-1); in mcd-1(n4005) animals,cells that would normally undergo apoptosis can instead pass through anepisode of pre-apoptotic condensation, after which they sometimes revertto normal shape, survive, and differentiate; MCD-1 contains anN-terminal low-complexity region and a single central zinc-finger, butno other recognizable protein domains; MCD-1 is paralogous to Y48E1B.7,but has no obvious non-nematode orthologs. | Paper_evidence | WBPaper00029005 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 23 May 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable metal ion binding activity. Involved in nematode larval development; positive regulation of growth rate; and programmed cell death. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y51H1A.6a | |||||||
| Y51H1A.6b | |||||||||
| Corresponding_CDS_history | Y51H1A.6:wp197 | ||||||||
| Corresponding_transcript | Y51H1A.6a.1 | ||||||||
| Y51H1A.6b.1 | |||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf644821 | ||||||||
| WBsf644822 | |||||||||
| WBsf990542 | |||||||||
| WBsf990543 | |||||||||
| WBsf990544 | |||||||||
| WBsf1013720 | |||||||||
| WBsf222409 | |||||||||
| Transcription_factor | WBTranscriptionFactor001099 | ||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern | Expr1014771 | ||||||||
| Expr1035812 | |||||||||
| Expr1160608 | |||||||||
| Expr2013446 | |||||||||
| Expr2031680 | |||||||||
| Drives_construct | WBCnstr00029758 | ||||||||
| Construct_product | WBCnstr00029758 | ||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction (25) | |||||||||
| Map_info | Map | II | Position | 21.0466 | Error | 0.088465 | |||
| Positive | Positive_clone | Y51H1A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00029005 | ||||||||
| WBPaper00032356 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
