WormBase Tree Display for Gene: WBGene00013463
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| WBGene00013463 | SMap | S_parent | Sequence | Y67H2A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | kdp-1 | Person_evidence | WBPerson622 | |||||
| Sequence_name | Y67H2A.5 | ||||||||
| Molecular_name | Y67H2A.5 | ||||||||
| Y67H2A.5.1 | |||||||||
| CE28376 | |||||||||
| Other_name | CELE_Y67H2A.5 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | kdp-1 | ||||||||
| DB_info | Database | AceView | gene | 4O65 | |||||
| WormQTL | gene | WBGene00013463 | |||||||
| WormFlux | gene | WBGene00013463 | |||||||
| OMIM | disease | 610743 | |||||||
| 612998 | |||||||||
| NDB | locus_tag | CELE_Y67H2A.5 | |||||||
| NCBI | gene | 178288 | |||||||
| RefSeq | protein | NM_070155.6 | |||||||
| TREEFAM | TREEFAM_ID | TF319632 | |||||||
| TrEMBL | UniProtAcc | Q95PZ1 | |||||||
| UniProt_GCRP | UniProtAcc | Q95PZ1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 29 Nov 2016 11:06:21 | WBPerson2970 | Name_change | CGC_name | kdp-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kdp | ||||||||
| Allele (16) | |||||||||
| Strain | WBStrain00051407 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00088009 | ||||||||
| 00088010 | |||||||||
| 00088011 | |||||||||
| 00088012 | |||||||||
| Contained_in_operon | CEOP4538 | ||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | Y67H2A.5 encodes a KASH domain (klarsicht, ANC-1 and Syne) protein; vertebrate KASH domain proteins include SYNE1 and SYNE2; most KASH domain proteins do not share primary sequence homology outside of their KASH domain; Y67H2A.5 is required for meiotic progression in the gonad and normal cell cycle progression in the early embryo; knock-down of Y67H2A.5 results in embryonic and larval lethalities; Y67H2A.5 encoded protein binds to the SUN domain proteins UNC-84 and SUN-1, and localizes to the nuclear envelope in a SUN-1 dependent manner. | Paper_evidence | WBPaper00040268 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 16 Mar 2012 00:00:00 | ||||||||
| Automated_description | Located in cytoplasm and nuclear envelope. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Disease_relevance | Studies in elegans have contributed much to the knowledge of SUN-KASH protein complexes which link components of the nucleus to the cytoplasm; the family of mammalian KASH (klarsicht, ANC-1 and Syne) domain proteins include Nesprin-1/SYNE1, Nesprin-2/SYNE2, Nesprin-3/SYNE3 and Nesprin-4/SYNE4) that encode at least 12 isoforms, by alternative transcription and splicing; most KASH domain proteins do not share primary sequence homology outside of their KASH domain; mutations in SYNE1, similar to those in LMNA/Lamin, cause laminopathic diseases like Emery-Dreifuss muscular dystrophy (EDMD) and Spinocerebellar ataxia. | Homo sapiens | Paper_evidence | WBPaper00040268 | ||||
| Accession_evidence | OMIM | 612998 | |||||||
| 610743 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Mar 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y67H2A.5 | |||||||
| Corresponding_transcript | Y67H2A.5.1 | ||||||||
| Other_sequence (100) | |||||||||
| Associated_feature | WBsf660882 | ||||||||
| WBsf229409 | |||||||||
| WBsf229410 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00085787 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00112512 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007462 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112513 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058010 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112511 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9000 | ||||||||
| Expr9001 | |||||||||
| Expr9537 | |||||||||
| Expr1025988 | |||||||||
| Expr1036021 | |||||||||
| Expr1161432 | |||||||||
| Expr2012918 | |||||||||
| Expr2031152 | |||||||||
| Drives_construct | WBCnstr00013666 | ||||||||
| Construct_product | WBCnstr00013666 | ||||||||
| WBCnstr00014102 | |||||||||
| Antibody | WBAntibody00002016 | ||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (105) | |||||||||
| SAGE_tag | SAGE:acaaggtttc | Strand | Antisense | ||||||
| SAGE:ggaaagtacggactcta | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:ggaaagtacg | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:agaaccgcca | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:gaaaagcgag | Strand | Antisense | |||||||
| SAGE:agaaccgccagcttcca | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:acaaggtttccgcattt | Strand | Antisense | |||||||
| Interaction (16) | |||||||||
| Map_info | Map | IV | Position | 8.51681 | |||||
| Positive | Positive_clone | Y67H2A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006488 | ||||||||
| WBPaper00035039 | |||||||||
| WBPaper00038444 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
