WormBase Tree Display for Gene: WBGene00013597
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| WBGene00013597 | SMap | S_parent | Sequence | Y87G2A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gpi-1 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | Y87G2A.8 | ||||||||
| Molecular_name | Y87G2A.8a | ||||||||
| Y87G2A.8a.1 | |||||||||
| CE24687 | |||||||||
| Y87G2A.8b | |||||||||
| CE36253 | |||||||||
| Y87G2A.8a.2 | |||||||||
| Y87G2A.8b.1 | |||||||||
| Other_name | CELE_Y87G2A.8 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | gpi-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 31 Aug 2005 14:07:05 | WBPerson2970 | Name_change | CGC_name | gpi-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gpi | ||||||||
| Allele (85) | |||||||||
| Strain | WBStrain00001272 | ||||||||
| WBStrain00037584 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP1704 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | gpi-1 encodes two isoforms of a putative glucose 6-phosphate isomeraseorthologous to human GPI (OMIM:172400, mutated in chronic hemolyticanemia); gpi-1 is required both for embryonic viability and(paradoxically) for normally short lifespan; gpi-1 is expressed inneurons and intestine. | Paper_evidence | WBPaper00004402 | |||||
| WBPaper00006525 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00026715 | |||||||||
| WBPaper00028588 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol. Expressed in head. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including congenital nonspherocytic hemolytic anemia; leukemia (multiple); and neuromuscular disease. Is an ortholog of human GPI (glucose-6-phosphate isomerase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4458) | |||||
| DOID:589 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4458) | ||||||
| DOID:440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4458) | ||||||
| DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4458) | ||||||
| DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4458) | ||||||
| DOID:2861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4458) | ||||||
| Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||||
| WBPaper00031384 | |||||||||
| WBPaper00025083 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Jan 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000338 | ||||||||
| Molecular_info | Corresponding_CDS | Y87G2A.8a | |||||||
| Y87G2A.8b | |||||||||
| Corresponding_transcript | Y87G2A.8a.1 | ||||||||
| Y87G2A.8a.2 | |||||||||
| Y87G2A.8b.1 | |||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf643807 | ||||||||
| WBsf643808 | |||||||||
| WBsf981130 | |||||||||
| WBsf985898 | |||||||||
| WBsf985899 | |||||||||
| WBsf1011093 | |||||||||
| WBsf1011094 | |||||||||
| WBsf218744 | |||||||||
| WBsf218745 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00058611 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00037909 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004846 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064005 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116719 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064006 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram2043 | ||||||||
| Expr7136 | |||||||||
| Expr1012129 | |||||||||
| Expr1036082 | |||||||||
| Expr1162033 | |||||||||
| Expr2012211 | |||||||||
| Expr2030447 | |||||||||
| Drives_construct | WBCnstr00002167 | ||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction (86) | |||||||||
| Map_info | Map | I | Position | 21.5103 | |||||
| Positive | Positive_clone | Y87G2A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (21.4937) | |||||||||
| Method | Gene |
