WormBase Tree Display for Gene: WBGene00013695
expand all nodes | collapse all nodes | view schema
WBGene00013695 | SMap | S_parent | Sequence | Y106G6A | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | ||||||||
Name | CGC_name | epg-8 | Paper_evidence | WBPaper00037833 | ||||||
Person_evidence | WBPerson716 | |||||||||
Sequence_name | Y106G6A.2 | |||||||||
Molecular_name | Y106G6A.2a | |||||||||
Y106G6A.2a.1 | ||||||||||
CE30567 | ||||||||||
Y106G6A.2c | ||||||||||
CE47002 | ||||||||||
Y106G6A.2d | ||||||||||
CE47053 | ||||||||||
Y106G6A.2b | ||||||||||
Y106G6A.2c.1 | ||||||||||
Y106G6A.2d.1 | ||||||||||
Other_name | CELE_Y106G6A.2 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | epg-8 | |||||||||
DB_info | Database (11) | |||||||||
Species | Caenorhabditis elegans | |||||||||
History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | |||
2 | 20 Aug 2004 17:09:32 | WBPerson1983 | Event | Changed_class | CDS | Transcript | ||||
3 | 05 Apr 2011 16:09:18 | WBPerson2970 | Name_change | CGC_name | epg-8 | |||||
Status | Live | |||||||||
Gene_info | Biotype | SO:0001217 | ||||||||
Gene_class | epg | |||||||||
Allele (26) | ||||||||||
Strain | WBStrain00032632 | |||||||||
WBStrain00008603 | ||||||||||
RNASeq_FPKM (74) | ||||||||||
GO_annotation (13) | ||||||||||
Ortholog (22) | ||||||||||
Structured_description | Concise_description | epg-8 encodes a coiled-coil domain protein that is conserved amongst nematodes; EPG-8 plays an essential role in autophagy, specifically in regulating the degradation of autophagic substrates as well as the normal levels and localization of LGG-1, the C. elegans Atg8 homolog; EPG-8 thus plays a role in regulating the survival of C. elegans under conditions of nutrient starvation; EPG-8 physically interacts with BEC-1, the C. elegans Beclin 1 homlog; an EGP-8 reporter fusion is widely expressed from embryogenesis through adulthood and localizes diffusely to the cytoplasm; based upon its physical interactions and biological role in C. elegans autophagy, epg-8 may be the functional homolog of budding yeast Atg14. | Paper_evidence | WBPaper00037833 | ||||||
Curator_confirmed | WBPerson1843 | |||||||||
Date_last_updated | 01 Apr 2011 00:00:00 | |||||||||
Automated_description | Involved in macroautophagy; positive regulation of autophagy; and positive regulation of embryonic development. Located in cytoplasm. Expressed in neurons and pharyngeal muscle cell. | Paper_evidence | WBPaper00065943 | |||||||
Curator_confirmed | WBPerson324 | |||||||||
WBPerson37462 | ||||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||||||
Modifies_disease | DOID:10652 | |||||||||
Modifies_disease_in_annotation | WBDOannot00001361 | |||||||||
Molecular_info | Corresponding_CDS | Y106G6A.2a | ||||||||
Y106G6A.2c | ||||||||||
Y106G6A.2d | ||||||||||
Corresponding_CDS_history | Y106G6A.2:wp77 | |||||||||
Y106G6A.2b:wp130 | ||||||||||
Corresponding_transcript (4) | ||||||||||
Other_sequence | CBC09731_1 | |||||||||
CBC09891_1 | ||||||||||
CBC13765_1 | ||||||||||
Associated_feature | WBsf649530 | |||||||||
WBsf649531 | ||||||||||
WBsf664803 | ||||||||||
WBsf664804 | ||||||||||
WBsf664805 | ||||||||||
WBsf220164 | ||||||||||
Experimental_info | RNAi_result (16) | |||||||||
Expr_pattern | Expr9166 | |||||||||
Expr1021170 | ||||||||||
Expr1036124 | ||||||||||
Expr1158786 | ||||||||||
Expr2011347 | ||||||||||
Expr2029583 | ||||||||||
Drives_construct | WBCnstr00007933 | |||||||||
WBCnstr00013762 | ||||||||||
WBCnstr00029561 | ||||||||||
Construct_product | WBCnstr00013762 | |||||||||
WBCnstr00029561 | ||||||||||
Microarray_results (32) | ||||||||||
Expression_cluster (113) | ||||||||||
Interaction (11) | ||||||||||
Map_info | Map | I | Position | 4.0707 | Error | 0.008 | ||||
Positive | Positive_clone | Y106G6A | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Pseudo_map_position | ||||||||||
Reference (16) | ||||||||||
Remark | .2b isoform changed from CDS to non-coding transcript, 2a isoform is still a CDS | Curator_confirmed | WBPerson1971 | |||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||||
Method | Gene |