WormBase Tree Display for Gene: WBGene00013785

WBGene00013785 SMap: S_parent: Sequence: Y116A8C
  Identity: Version: 2
    Name: CGC_name: nep-23 Person_evidence: WBPerson260
      Sequence_name: Y116A8C.4
      Molecular_name: Y116A8C.4
        Y116A8C.4.1
        CE40629
      Other_name: CELE_Y116A8C.4 Accession_evidence: NDB BX284604
      Public_name: nep-23
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 10 Feb 2012 15:49:10 WBPerson2970 Name_change: CGC_name: nep-23
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nep
    Allele (184)
    Strain: WBStrain00037265
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (65)
    Paralog (24)
    Structured_description: Concise_description: Y116A8C.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; Y116A8C.4 has no clear orthologs in other organisms. Paper_evidence: WBPaper00004584
            WBPaper00013276
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Is an ortholog of human ECEL1 (endothelin converting enzyme like 1) and KEL (Kell metallo-endopeptidase (Kell blood group)). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111594 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3147)
  Molecular_info: Corresponding_CDS: Y116A8C.4
    Corresponding_CDS_history: Y116A8C.4:wp168
    Corresponding_transcript: Y116A8C.4.1
    Associated_feature: WBsf229615
  Experimental_info: RNAi_result: WBRNAi00019931 Inferred_automatically: RNAi_primary
      WBRNAi00089185 Inferred_automatically: RNAi_primary
      WBRNAi00108668 Inferred_automatically: RNAi_primary
      WBRNAi00108593 Inferred_automatically: RNAi_primary
      WBRNAi00007425 Inferred_automatically: RNAi_primary
      WBRNAi00055457 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1028462
      Expr1158968
      Expr2013968
      Expr2032207
    Drives_construct: WBCnstr00029524
    Construct_product: WBCnstr00029524
    Microarray_results (17)
    Expression_cluster (142)
    Interaction: WBInteraction000205307
      WBInteraction000261371
      WBInteraction000329812
      WBInteraction000422518
      WBInteraction000520097
      WBInteraction000536640
      WBInteraction000536715
  Map_info: Map: IV Position: 15.7797
    Positive: Positive_clone: Y116A8C Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene