WormBase Tree Display for Gene: WBGene00014028
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| WBGene00014028 | SMap | S_parent | Sequence | ZK637 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | trxr-2 | Person_evidence | WBPerson3046 | |||||
| Sequence_name | ZK637.10 | ||||||||
| Molecular_name | ZK637.10 | ||||||||
| ZK637.10.1 | |||||||||
| CE15373 | |||||||||
| Other_name | CELE_ZK637.10 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | trxr-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 06 May 2005 10:44:15 | WBPerson2970 | Name_change | CGC_name | trxr-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | trxr | ||||||||
| Allele (30) | |||||||||
| Strain | WBStrain00032455 | ||||||||
| WBStrain00040310 | |||||||||
| WBStrain00040312 | |||||||||
| WBStrain00040313 | |||||||||
| WBStrain00040314 | |||||||||
| WBStrain00040315 | |||||||||
| WBStrain00040316 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP3556 | ||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00015553 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006937 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007744 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008117 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010794 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017640 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | trxr-2 encodes a thioredoxin reductase; TRXR-2 exhibits catalytic activity in vitro, reducing the redox-active disulfide bond of thioredoxin; large-scale expression studies indicate that a trxr-2::gfp reporter fusion is expressed in the intestine and in neurons. | Paper_evidence | WBPaper00030884 | |||||
| WBPaper00031006 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Dec 2010 00:00:00 | ||||||||
| Automated_description | Enables thioredoxin-disulfide reductase (NADP) activity. Involved in obsolete oxidation-reduction process. Located in mitochondrion. Expressed in intestine; muscle cell; nervous system; and vulva. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Is an ortholog of human TXNRD2 (thioredoxin reductase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0080620 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18155) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including TXNRD2 (thioredoxin reductase 2); the C. elegans ortholog, trxr-2 is mitochondrial and protects mitochondria from oxidative stress, gene knockdown animals show hypersensitivity to protein aggregation-induced paralysis; trxr-2 is upregulated in response to heat shock; trxr-2 is a potential model system to study genes involved in 22q11.2DS. | Homo sapiens | Paper_evidence | WBPaper00041336 | |||||
| WBPaper00047004 | |||||||||
| Accession_evidence | OMIM | 611867 | |||||||
| 606448 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000370 | ||||||||
| Molecular_info | Corresponding_CDS | ZK637.10 | |||||||
| Corresponding_transcript | ZK637.10.1 | ||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf225491 | ||||||||
| WBsf225492 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr7232 | ||||||||
| Expr9919 | |||||||||
| Expr10548 | |||||||||
| Expr1013660 | |||||||||
| Expr1036276 | |||||||||
| Expr1162997 | |||||||||
| Expr2017524 | |||||||||
| Expr2035662 | |||||||||
| Drives_construct | WBCnstr00000434 | ||||||||
| WBCnstr00002773 | |||||||||
| WBCnstr00010010 | |||||||||
| WBCnstr00010011 | |||||||||
| WBCnstr00015467 | |||||||||
| WBCnstr00015469 | |||||||||
| WBCnstr00015470 | |||||||||
| WBCnstr00015471 | |||||||||
| WBCnstr00015754 | |||||||||
| Construct_product | WBCnstr00000434 | ||||||||
| WBCnstr00009808 | |||||||||
| WBCnstr00010009 | |||||||||
| WBCnstr00010011 | |||||||||
| WBCnstr00010017 | |||||||||
| WBCnstr00015467 | |||||||||
| WBCnstr00015471 | |||||||||
| WBCnstr00015754 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (84) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | III | Position | 0.025155 | Error | 0.006161 | |||
| Positive | Positive_clone | ZK637 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5518 | |||||||
| 4187 | |||||||||
| 5435 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
