WormBase Tree Display for Gene: WBGene00014989

WBGene00014989 SMap: S_parent: Sequence: ZK675
  Identity: Version: 2
    Name: CGC_name: best-23 Person_evidence: WBPerson260
      Sequence_name: ZK675.3
      Molecular_name: ZK675.3a
        ZK675.3a.1
        CE01722
        ZK675.3b
      Other_name: CELE_ZK675.3 Accession_evidence: NDB BX284602
      Public_name: best-23
    DB_info: Database: AceView gene 2I196
        WormFlux gene WBGene00014989
        NDB locus_tag CELE_ZK675.3
        Panther gene CAEEL|WormBase=WBGene00014989|UniProtKB=A5JYR2
          family PTHR10736
        NCBI gene 6418643
        RefSeq protein NM_001129196.5
            NR_023956.1
        TrEMBL UniProtAcc A5JYR2
        UniProt_GCRP UniProtAcc A5JYR2
        OMIM gene 607854
        RNAcentral URSid URS0000182276
    Species: Caenorhabditis elegans
    History: Version_change: 1 27 May 2004 15:23:24 WBPerson1971 Event: Imported: Initial conversion from Pseudogene class of WS125
        2 07 Feb 2012 16:30:56 WBPerson2970 Name_change: CGC_name: best-23
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: best
    Allele (42)
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (36)
    Paralog (26)
    Structured_description: Automated_description: Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy and retinal degeneration (multiple). Is an ortholog of several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110396 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0050661 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0050662 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0111569 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
  Molecular_info: Corresponding_CDS: ZK675.3a
    Corresponding_CDS_history: ZK675.3:wp39
      ZK675.3:wp91
    Corresponding_transcript: ZK675.3b
      ZK675.3a.1
    Corresponding_pseudogene_history: ZK675.3:wp175
    Other_sequence (12)
    Associated_feature: WBsf665750
      WBsf665751
      WBsf988600
      WBsf988601
      WBsf223416
  Experimental_info: RNAi_result: WBRNAi00022121 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1021102
      Expr1036409
      Expr1163062
      Expr2009605
      Expr2027842
    Drives_construct: WBCnstr00029173
    Construct_product: WBCnstr00029173
    Microarray_results (17)
    Expression_cluster (121)
  Map_info: Map: II Position: 0.609528
    Positive: Positive_clone: ZK675 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene