WormBase Tree Display for Gene: WBGene00015399
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WBGene00015399 | SMap | S_parent | Sequence | C03G6 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | cyp-35A1 | |||||
Sequence_name | C03G6.14 | ||||||
Molecular_name | C03G6.14 | ||||||
C03G6.14.1 | |||||||
CE52081 | |||||||
Other_name | CELE_C03G6.14 | Accession_evidence | NDB | BX284605 | |||
Public_name | cyp-35A1 | ||||||
DB_info | Database | AceView | gene | 5H838 | |||
WormQTL | gene | WBGene00015399 | |||||
WormFlux | gene | WBGene00015399 | |||||
NDB | locus_tag | CELE_C03G6.14 | |||||
Panther | gene | CAEEL|WormBase=WBGene00015399|UniProtKB=O02627 | |||||
family | PTHR24300 | ||||||
NCBI | gene | 182176 | |||||
RefSeq | protein | NM_001356694.2 | |||||
TrEMBL | UniProtAcc | O02627 | |||||
UniProt_GCRP | UniProtAcc | O02627 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cyp | ||||||
Allele (40) | |||||||
Strain | WBStrain00032479 | ||||||
WBStrain00036139 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Ortholog (129) | |||||||
Paralog (44) | |||||||
Structured_description | Concise_description | cyp-35A1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35A1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; inaddition, cyp-35A(RNAi) also results in a reduction of fat content. | Paper_evidence | WBPaper00005655 | |||
WBPaper00025207 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 26 Feb 2009 00:00:00 | ||||||
Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (42) | ||||||
Molecular_info | Corresponding_CDS | C03G6.14 | |||||
Corresponding_CDS_history | C03G6.14:wp125 | ||||||
C03G6.14:wp185 | |||||||
C03G6.14:wp261 | |||||||
Corresponding_transcript | C03G6.14.1 | ||||||
Other_sequence | Dviv_isotig14097 | ||||||
Dviv_isotig14098 | |||||||
AM743893.1 | |||||||
Oden_isotig18384 | |||||||
Experimental_info | RNAi_result | WBRNAi00078473 | Inferred_automatically | RNAi_primary | |||
WBRNAi00078474 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00039542 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00010067 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00114817 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092681 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1017756 | ||||||
Expr1143646 | |||||||
Expr2010734 | |||||||
Drives_construct | WBCnstr00028874 | ||||||
Construct_product | WBCnstr00028874 | ||||||
Microarray_results (15) | |||||||
Expression_cluster (111) | |||||||
Interaction (28) | |||||||
Map_info | Map | V | Position | 0.708623 | Error | 0.002847 | |
Positive | Positive_clone | C03G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5576 | |||||
Pseudo_map_position | |||||||
Reference (11) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |