WormBase Tree Display for Gene: WBGene00015547
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WBGene00015547 | SMap | S_parent | Sequence | C06G1 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ain | ||||||
Allele (55) | |||||||
Strain | WBStrain00026530 | ||||||
WBStrain00026534 | |||||||
WBStrain00034970 | |||||||
WBStrain00054873 | |||||||
WBStrain00054872 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (26) | |||||||
Structured_description | Concise_description | ain-1 encodes an unfamiliar protein synergistically required, withLIN-31, for the normal timing of vulval differentiation, independentlyof LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1;AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) inseveral tissues, including vulval precursor cells and neurons; AIN-1coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro,and does not require DNA or RNA for its binding; in vivo, AIN-1 targetsALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2; AIN-1 islikely to be a RISC component, since anti-AIN-1 antibodies precipitate29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77,and mir-239a; ain-1(ku322) mutants are essentially wild-type, except forsporadically gapped alae and excess seam cell nuclei arising fromretarded seam cell fusion; more prominently, ain-1(ku322) suppresses themultivulva phenotype of lin-31(n1053) mutations, while stronglyenhancing lin-31(n1053)'s egg-laying defect; the cellular basis oflin-31(n1053);ain-1(ku322) phenotypes is a delay in vulval developmentin L4 larvae not seen with either mutation alone; ain-1(ku322) has noeffect on let-60(n1046) or lin-3(e1275) mutations; ain-1(ku322)suppresses the precocious vulval development of lin-14(RNAi), lin-28mutants, and hbl-1(RNAi); alg-1 or alg-1 ain-1 mutant alae resembleain-1 alae, indicating that ALG-1 and AIN-1 act in a common geneticpathway; AIN-1 is homologous to Brugia malayi 14748.m00068,14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2;AIN-1 and its nematode homologs have weak similarity to human TNRC6A(GW182; OMIM:610739) and Drosophila GAWKY. | Paper_evidence | WBPaper00026707 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 07 May 2007 00:00:00 | ||||||
Automated_description | Involved in several processes, including embryo development; negative regulation of gene expression; and regulation of developmental process. Located in P-body. Expressed widely. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C06G1.4 | |||||
Corresponding_CDS_history | C06G1.4:wp95 | ||||||
C06G1.4:wp99 | |||||||
Corresponding_transcript | C06G1.4.1 | ||||||
Other_sequence (15) | |||||||
Associated_feature (15) | |||||||
Experimental_info | RNAi_result (16) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00009448 | ||||||
WBCnstr00011571 | |||||||
WBCnstr00014500 | |||||||
WBCnstr00017585 | |||||||
WBCnstr00018660 | |||||||
WBCnstr00019818 | |||||||
WBCnstr00028761 | |||||||
WBCnstr00039524 | |||||||
Construct_product | WBCnstr00011571 | ||||||
WBCnstr00018660 | |||||||
WBCnstr00019818 | |||||||
WBCnstr00028761 | |||||||
WBCnstr00039524 | |||||||
Regulate_expr_cluster | WBPaper00031252:AIN-1_IP_enriched | ||||||
Antibody | WBAntibody00001341 | ||||||
WBAntibody00002435 | |||||||
WBAntibody00002673 | |||||||
WBAntibody00002711 | |||||||
Microarray_results (24) | |||||||
Expression_cluster (151) | |||||||
Interaction (458) | |||||||
Map_info | Map | X | Position | 24.0566 | Error | 0.000506 | |
Positive | Positive_clone | C06G1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (40) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |