WormBase Tree Display for Gene: WBGene00015658
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WBGene00015658 | SMap | S_parent | Sequence | C09G12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | tsg-101 | Person_evidence | WBPerson3188 | |||||
WBPerson1816 | |||||||||
Sequence_name | C09G12.9 | ||||||||
Molecular_name | C09G12.9 | ||||||||
C09G12.9.1 | |||||||||
CE34675 | |||||||||
Other_name | CELE_C09G12.9 | Accession_evidence | NDB | BX284604 | |||||
Public_name | tsg-101 | ||||||||
DB_info | Database | AceView | gene | 4E276 | |||||
WormQTL | gene | WBGene00015658 | |||||||
WormFlux | gene | WBGene00015658 | |||||||
NDB | locus_tag | CELE_C09G12.9 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00015658|UniProtKB=O76258 | |||||||
family | PTHR23306 | ||||||||
NCBI | gene | 182474 | |||||||
RefSeq | protein | NM_067963.6 | |||||||
TREEFAM | TREEFAM_ID | TF312917 | |||||||
TrEMBL | UniProtAcc | O76258 | |||||||
UniProt_GCRP | UniProtAcc | O76258 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 30 Oct 2007 14:27:24 | WBPerson2970 | Name_change | CGC_name | tsg-101 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | tsg | ||||||||
Allele (77) | |||||||||
Strain | WBStrain00002625 | ||||||||
WBStrain00002534 | |||||||||
WBStrain00051306 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (13) | |||||||||
Contained_in_operon | CEOP4088 | ||||||||
Ortholog (46) | |||||||||
Structured_description | Concise_description | tsg-101 encodes the C. elegans ortholog of S. cerevisiae vacuolar protein sorting protein Vps23p and human TUMOR SUSCEPTIBILITY GENE 101 (TSG101; OMIM:601387), mutations in which are associated with several types of cancer and with varying responses to HIV infection; TSG-101 is an essential component of the C. elegans ESCRT-1 (Endosomal Sorting Complex Required for Transport, other members include VPS-28, VPS-37, and MVB-12) that is required for cell surface receptor degradation via the multivesicular body sorting pathway and hence, downregulation of receptor activity. | Paper_evidence | WBPaper00026641 | |||||
WBPaper00031035 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 09 Jul 2010 00:00:00 | ||||||||
Automated_description | Predicted to enable ubiquitin binding activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway and receptor catabolic process. Located in endosome membrane. Part of ESCRT I complex. Expressed in head and tail. Human ortholog(s) of this gene implicated in breast carcinoma and reproductive organ cancer (multiple). Is an ortholog of human TSG101 (tumor susceptibility 101). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||
DOID:2893 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
DOID:2870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15971) | ||||||
Molecular_info | Corresponding_CDS | C09G12.9 | |||||||
Corresponding_CDS_history | C09G12.9:wp105 | ||||||||
Corresponding_transcript | C09G12.9.1 | ||||||||
Other_sequence (26) | |||||||||
Associated_feature | WBsf667837 | ||||||||
Experimental_info | RNAi_result (12) | ||||||||
Expr_pattern | Chronogram751 | ||||||||
Chronogram1424 | |||||||||
Expr5223 | |||||||||
Expr5224 | |||||||||
Expr1020827 | |||||||||
Expr1036705 | |||||||||
Expr1144298 | |||||||||
Expr2017537 | |||||||||
Expr2035675 | |||||||||
Drives_construct | WBCnstr00003110 | ||||||||
WBCnstr00004547 | |||||||||
WBCnstr00028680 | |||||||||
Construct_product | WBCnstr00028680 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (76) | |||||||||
Interaction (45) | |||||||||
Map_info | Map | IV | Position | -3.31212 | Error | 0.00351 | |||
Positive | Positive_clone | C09G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (12) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |