WormBase Tree Display for Gene: WBGene00016005
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| WBGene00016005 | SMap | S_parent | Sequence | C18H9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ift-74 | Person_evidence | WBPerson426 | |||||
| Sequence_name | C18H9.8 | ||||||||
| Molecular_name | C18H9.8a | ||||||||
| C18H9.8a.1 | |||||||||
| CE52310 | |||||||||
| C18H9.8b | |||||||||
| CE52146 | |||||||||
| C18H9.8b.1 | |||||||||
| Other_name | CELE_C18H9.8 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ift-74 | ||||||||
| DB_info | Database | AceView | gene | 2G971 | |||||
| WormQTL | gene | WBGene00016005 | |||||||
| WormFlux | gene | WBGene00016005 | |||||||
| NDB | locus_tag | CELE_C18H9.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016005|UniProtKB=A0A2C9C2L6 | |||||||
| family | PTHR31432 | ||||||||
| NCBI | gene | 174102 | |||||||
| RefSeq | protein | NM_062958.6 | |||||||
| NM_001356863.3 | |||||||||
| TrEMBL | UniProtAcc | A0A2C9C2L6 | |||||||
| A0A2C9C2S9 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A2C9C2L6 | |||||||
| OMIM | gene | 608040 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 Sep 2006 09:01:01 | WBPerson2970 | Name_change | CGC_name | ift-74 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ift | ||||||||
| Allele (44) | |||||||||
| Strain | WBStrain00032266 | ||||||||
| WBStrain00032844 | |||||||||
| WBStrain00037107 | |||||||||
| WBStrain00007577 | |||||||||
| WBStrain00007886 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (31) | |||||||||
| Structured_description | Concise_description | ift-74 encodes a protein that interacts with the intraflagellar transport (IFT) component IFT-81; ift-74 along with ift-81 is involved in growth, chemotaxis, intraflagellar transport and the morphogenesis of cilia; ift-74 colocalizes with ift-81 in the ciliary transition zone; ift-74 binds ift-81 in protien binding assays; the physical interaction of ift-74 and ift-81 and their co-localization indicate that they might form a complex in ciliated neurons. | Paper_evidence | WBPaper00030726 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 27 Oct 2008 00:00:00 | ||||||||
| Automated_description | Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Is an ortholog of human IFT74 (intraflagellar transport 74). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21424) | ||||
| DOID:0081011 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21424) | ||||||
| DOID:0050777 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21424) | ||||||
| Molecular_info | Corresponding_CDS | C18H9.8a | |||||||
| C18H9.8b | |||||||||
| Corresponding_CDS_history | C18H9.8:wp261 | ||||||||
| Corresponding_transcript | C18H9.8a.1 | ||||||||
| C18H9.8b.1 | |||||||||
| Associated_feature | WBsf657198 | ||||||||
| WBsf657703 | |||||||||
| WBsf988224 | |||||||||
| WBsf1012409 | |||||||||
| WBsf221488 | |||||||||
| WBsf221489 | |||||||||
| WBsf221490 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00040997 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00011044 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1020125 | ||||||||
| Expr1036835 | |||||||||
| Expr1145044 | |||||||||
| Expr2012698 | |||||||||
| Expr2030934 | |||||||||
| Drives_construct | WBCnstr00028392 | ||||||||
| Construct_product | WBCnstr00028392 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (184) | |||||||||
| SAGE_tag (12) | |||||||||
| Interaction (24) | |||||||||
| Map_info | Map | II | Position | -0.042458 | Error | 0.006117 | |||
| Positive | Positive_clone | C18H9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00029016 | ||||||||
| WBPaper00030726 | |||||||||
| WBPaper00031170 | |||||||||
| WBPaper00037724 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056552 | |||||||||
| WBPaper00062114 | |||||||||
| WBPaper00064360 | |||||||||
| WBPaper00065994 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
