WormBase Tree Display for Gene: WBGene00016704
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| WBGene00016704 | SMap | S_parent | Sequence | C46C11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | hosl-1 | Person_evidence | WBPerson542 | |||||
| WBPerson2105 | |||||||||
| Sequence_name | C46C11.1 | ||||||||
| Molecular_name | C46C11.1a | ||||||||
| C46C11.1a.1 | |||||||||
| CE27859 | |||||||||
| C46C11.1b | |||||||||
| CE39698 | |||||||||
| C46C11.1b.1 | |||||||||
| Other_name | CELE_C46C11.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | hosl-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 15 Mar 2013 16:30:53 | WBPerson2970 | Name_change | CGC_name | hosl-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hosl | ||||||||
| Allele (85) | |||||||||
| Strain | WBStrain00002977 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00008407 | ||||||||
| 00008408 | |||||||||
| 00008409 | |||||||||
| 00008410 | |||||||||
| 00122260 | |||||||||
| 00122261 | |||||||||
| 00122262 | |||||||||
| 00122263 | |||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | hosl-1 encodes the C. elegans ortholog of hormone-sensitive lipase (LIPE); by homology, HOSL-1 is predicted to function in the regulation of energy homeostasis and fat metabolism by catalyzing the first, rate-limiting step of triglyceride hydrolysis; hosl-1(RNAi) suppresses the egg-laying defective phenotype of egl-9(sa307) mutants; large-scale expression studies suggest that hosl-1 is expressed in a variety of tissues including the pharynx, intestine, hypodermis, and nervous system. | Paper_evidence | WBPaper00031006 | |||||
| WBPaper00031018 | |||||||||
| WBPaper00032396 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Feb 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable sterol esterase activity and triglyceride lipase activity. Predicted to be involved in triglyceride catabolic process. Predicted to be located in cytosol. Expressed in tail. Human ortholog(s) of this gene implicated in artery disease (multiple); familial partial lipodystrophy type 6; and type 2 diabetes mellitus. Is an ortholog of human LIPE (lipase E, hormone sensitive type). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070206 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6621) | ||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6621) | ||||||
| DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6621) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6621) | ||||||
| Molecular_info | Corresponding_CDS | C46C11.1a | |||||||
| C46C11.1b | |||||||||
| Corresponding_CDS_history | C46C11.1:wp154 | ||||||||
| Corresponding_transcript | C46C11.1a.1 | ||||||||
| C46C11.1b.1 | |||||||||
| Other_sequence (20) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00070898 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00102723 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012020 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029855 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070899 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102881 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102721 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102665 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042585 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram783 | ||||||||
| Expr5513 | |||||||||
| Expr5514 | |||||||||
| Expr1019663 | |||||||||
| Expr1037172 | |||||||||
| Expr1146566 | |||||||||
| Expr2012538 | |||||||||
| Expr2030777 | |||||||||
| Drives_construct | WBCnstr00003482 | ||||||||
| WBCnstr00004592 | |||||||||
| WBCnstr00027871 | |||||||||
| Construct_product | WBCnstr00027871 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (11) | |||||||||
| Map_info | Map | X | Position | -7.09829 | |||||
| Positive | Positive_clone | C46C11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
