WormBase Tree Display for Gene: WBGene00016786

WBGene00016786 SMap: S_parent: Sequence: C49G7
  Identity: Version: 2
    Name: CGC_name: cyp-35A4
      Sequence_name: C49G7.8
      Molecular_name: C49G7.8
        C49G7.8.1
        CE08866
      Other_name: CELE_C49G7.8 Accession_evidence: NDB BX284605
      Public_name: cyp-35A4
    DB_info: Database: AceView gene 5E505
        WormQTL gene WBGene00016786
        WormFlux gene WBGene00016786
        NDB locus_tag CELE_C49G7.8
        Panther gene CAEEL|WormBase=WBGene00016786|UniProtKB=O16220
          family PTHR24300
        NCBI gene 183622
        RefSeq protein NM_071723.2
        TrEMBL UniProtAcc O16220
        UniProt_GCRP UniProtAcc O16220
        OMIM gene 601130
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-35A4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (89)
    Strain: WBStrain00031993
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (178)
    Paralog (44)
    Structured_description: Concise_description: cyp-35A4 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; in addition, cyp-35A(RNAi) also results in a reduction of fat content. Paper_evidence: WBPaper00005655
            WBPaper00025207
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (57)
  Molecular_info: Corresponding_CDS: C49G7.8
    Corresponding_transcript: C49G7.8.1
    Other_sequence: Acan_isotig10101
      Oden_isotig22190
      Tcol_isotig14390
      CBC02873_1
      Hbac_isotig01197
    Associated_feature: WBsf646736
      WBsf999724
      WBsf1019456
      WBsf231625
      WBsf231626
      WBsf231627
  Experimental_info: RNAi_result: WBRNAi00112265 Inferred_automatically: RNAi_primary
      WBRNAi00116297 Inferred_automatically: RNAi_primary
      WBRNAi00042829 Inferred_automatically: RNAi_primary
      WBRNAi00092684 Inferred_automatically: RNAi_primary
      WBRNAi00078477 Inferred_automatically: RNAi_primary
      WBRNAi00042828 Inferred_automatically: RNAi_primary
      WBRNAi00012159 Inferred_automatically: RNAi_primary
      WBRNAi00114820 Inferred_automatically: RNAi_primary
      WBRNAi00029993 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1021889
      Expr1146808
      Expr2010737
      Expr2028974
    Drives_construct: WBCnstr00027804
    Construct_product: WBCnstr00027804
    Microarray_results (17)
    Expression_cluster (193)
    Interaction (23)
  Map_info: Map: V Position: -7.0059 Error: 0.015996
    Positive: Positive_clone: C49G7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4937
        5043
        5427
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene