WormBase Tree Display for Gene: WBGene00017046
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| WBGene00017046 | SMap | S_parent | Sequence | D2021 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | utx-1 | Person_evidence | WBPerson1422 | |||||
| Sequence_name | D2021.1 | ||||||||
| Molecular_name | D2021.1a | ||||||||
| D2021.1a.1 | |||||||||
| CE51475 | |||||||||
| D2021.1b | |||||||||
| CE51318 | |||||||||
| D2021.1b.1 | |||||||||
| Other_name | CELE_D2021.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | utx-1 | ||||||||
| DB_info | Database | AceView | gene | XJ181 | |||||
| WormQTL | gene | WBGene00017046 | |||||||
| WormFlux | gene | WBGene00017046 | |||||||
| NDB | locus_tag | CELE_D2021.1 | |||||||
| Panther | gene | CAEEL|Gene_ORFName=CELE_D2021.1|UniProtKB=A0A131MBT2 | |||||||
| family | PTHR14017 | ||||||||
| NCBI | gene | 181110 | |||||||
| RefSeq | protein | NM_001322626.4 | |||||||
| NM_001322627.4 | |||||||||
| TrEMBL | UniProtAcc | A0A131MBT2 | |||||||
| A0A131MCP7 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A131MBT2 | |||||||
| OMIM | gene | 300128 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 08 Jun 2007 15:14:26 | WBPerson2970 | Name_change | CGC_name | utx-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | utx | ||||||||
| Allele (80) | |||||||||
| Strain | WBStrain00037577 | ||||||||
| Component_of_genotype | WBGenotype00000101 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00007813 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00009089 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00017571 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | utx-1 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase, required for embryonic viability and vulval development, and for high brood sizes, locomotion, and growth sizes; UTX-1 contains a JmjC domain, is orthologous to human UTX and UTY, and is paralogous to human JMJD3; by orthology, UTX-1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes. | Paper_evidence | WBPaper00005599 | |||||
| WBPaper00006395 | |||||||||
| WBPaper00027108 | |||||||||
| WBPaper00030964 | |||||||||
| WBPaper00031022 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 01 Oct 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Involved in cell fate specification and programmed cell death. Part of MLL3/4 complex. Expressed in several structures, including germ line; gonad; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; breast cancer (multiple); and carcinoma (multiple). Is an ortholog of human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (18) | ||||||||
| Modifies_disease | DOID:332 | ||||||||
| DOID:9255 | |||||||||
| Modifies_disease_in_annotation | WBDOannot00001143 | ||||||||
| WBDOannot00001144 | |||||||||
| Molecular_info | Corresponding_CDS | D2021.1a | |||||||
| D2021.1b | |||||||||
| Corresponding_CDS_history | D2021.1:wp252 | ||||||||
| Corresponding_transcript | D2021.1a.1 | ||||||||
| D2021.1b.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (39) | ||||||||
| Expr_pattern | Expr9611 | ||||||||
| Expr10047 | |||||||||
| Expr13090 | |||||||||
| Expr13107 | |||||||||
| Expr1023651 | |||||||||
| Expr1037324 | |||||||||
| Expr1147442 | |||||||||
| Expr2017943 | |||||||||
| Expr2036079 | |||||||||
| Drives_construct | WBCnstr00014172 | ||||||||
| WBCnstr00015020 | |||||||||
| WBCnstr00027611 | |||||||||
| WBCnstr00038058 | |||||||||
| WBCnstr00038060 | |||||||||
| Construct_product | WBCnstr00015020 | ||||||||
| WBCnstr00016319 | |||||||||
| WBCnstr00027611 | |||||||||
| WBCnstr00038060 | |||||||||
| Antibody | WBAntibody00002333 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (168) | |||||||||
| Interaction (74) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | X | Position | 0.112824 | Error | 0.003583 | |||
| Positive | Positive_clone | D2021 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (39) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
