WormBase Tree Display for Gene: WBGene00017553

WBGene00017553 SMap: S_parent: Sequence: F18A12
  Identity: Version: 2
    Name: CGC_name: nep-8 Person_evidence: WBPerson260
      Sequence_name: F18A12.4
      Molecular_name (12)
      Other_name: CELE_F18A12.4 Accession_evidence: NDB BX284602
      Public_name: nep-8
    DB_info: Database: AceView gene 2D697
        WormQTL gene WBGene00017553
        WormFlux gene WBGene00017553
        NDB locus_tag CELE_F18A12.4
        Panther gene CAEEL|Gene_ORFName=CELE_F18A12.4|UniProtKB=A0A131MCS3
          family PTHR11733
        NCBI gene 184631
        RefSeq protein NM_001322723.3
            NM_001322721.2
            NM_001322724.3
            NM_001322722.4
        TrEMBL UniProtAcc A0A131MBF3
            A0A131MCS3
            A0A131MAS8
            A0A131MAX6
        UniProt_GCRP UniProtAcc A0A131MCS3
        OMIM gene 605896
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 10 Feb 2012 15:49:10 WBPerson2970 Name_change: CGC_name: nep-8
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nep
    Allele (103)
    Strain: WBStrain00051456
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (60)
    Paralog (24)
    Structured_description: Concise_description: F18A12.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.4 has no clear orthologs in other organisms. Paper_evidence: WBPaper00004584
            WBPaper00013276
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Is an ortholog of human ECEL1 (endothelin converting enzyme like 1) and KEL (Kell metallo-endopeptidase (Kell blood group)). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111594 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3147)
  Molecular_info: Corresponding_CDS: F18A12.4a
      F18A12.4b
      F18A12.4c
      F18A12.4d
    Corresponding_CDS_history: F18A12.4:wp125
      F18A12.4:wp252
    Corresponding_transcript: F18A12.4a.1
      F18A12.4b.1
      F18A12.4c.1
      F18A12.4d.1
  Experimental_info: RNAi_result: WBRNAi00044925 Inferred_automatically: RNAi_primary
      WBRNAi00089042 Inferred_automatically: RNAi_primary
      WBRNAi00013493 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016428
      Expr1037537
      Expr1148891
      Expr2013975
      Expr2032215
    Drives_construct: WBCnstr00027211
    Construct_product: WBCnstr00027211
    Microarray_results (17)
    Expression_cluster (167)
    Interaction (18)
  Map_info: Map: II Position: -6.31222
    Positive: Positive_clone: F18A12 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00065080
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene